stem cells and the immune system

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the immune system stem cells and the immune system january 2010 * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response immune suppression and tolerance * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response natural killer cells * brainstorm why do organisms contract diseases? what happens when an organism contracts a disease? what factors can help (or hinder) the likelihood that we will contract a disease? what happens when an organism is injured? what factors can help (or hinder) the likelihood that we will recover from an injury? * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response natural killer cells * basic organization and function of the immune system the immune system is the body’s response to disease and injury nonspecific response (innate immunity) …

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cell division (one daughter stays in bone marrow ) lymphoid and myeloid lineage cells begin and are released from here differentiation into lymphoid stem cells in the bone marrow general b cells mature in the bone marrow differentiation into lymphoid stem cells in the thymus general t cells mature in the thymus * play “the cell is right” to learn about the blood tree * refer to the teacher guide at above link before playing. requires printing out pages preferably in color and set up beforehand. migration migration of mature general b and t cells to secondary lymphoid organs: lymph nodes spleen tonsils external body surfaces (intestinal, respiratory, urinary, reproductive) * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response immune suppression and tolerance * immune activation and response antigen-antibody binding structure, location and function of antibodies 1. tag and disable antigen …

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ural killer cells and macrophages * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response immune suppression and tolerance * why do stem cell transplants fail? immune issues impact stem cell therapies major histocompatibility complex is a person’s combination of cell surface proteins that lymphocytes use to tell “self” from “non-self” allogeneic transplants fail because there isn’t a match, and lymphocytes destroy the non-self cells allogeneic: taken from different individuals of the same species. two or more individuals are said to be allogeneic to one another when the genes at one or more loci are not identical. you may wish to talk about graft vs. host disease, another reason why stem cell transplants fail. here, immune cells from the donor are inevitably transplanted along with the stem cells. these will attack the patient’s tissues (invade from the outside). * immune tolerance research …

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the immune system stem cells and the immune system january 2010 * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response immune suppression and tolerance * today’s lecture brainstorm basic organization and function of the immune system lymphocyte development immune activation and response natural killer cells * brainstorm why do organisms contract diseases? what happens when an organism contracts a disease? what factors can help (or hinder) the likelihood that we will contract a disease? what happens when an organism is injured? what factors can help (or hinder) the likelihood that we will recover from an injury? * today’s lecture brainstorm basic organization and function of the immune system lymphocyte develop...

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