clinical pharmacology of non-steroidal anti-inflammatory drugs and immunomodulators

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subject number 8: "clinical pharmacology of non-steroidal anti-inflammatory drugs and immunomodulators" technology training (practical training) time: 270 minutes number of students: 8-9 the structure of the training session 6:00 practical lesson the structure of the lesson 1. introduction. 2. the theoretical part 3. the practical part (practical skills) 4. the analytical part (organizer, test and case studies) the purpose of the lesson: to teach students the knowledge of basic principles and umeneniyu individual selection of effective and safe nsaid with the pharmacodynamics, pharmacokinetics, side effects, and features action and its dependence on various factors (pregnancy, age, functional state of the metabolism and elimination). the student should know: -group drugs included in the standard treatment of pathology of the musculoskeletal system - the mechanism of action of nonsteroidal anti-inflammatory drugs - indications and contraindications to anti-inflammatory drugs - side effects of anti-inflammatory drugs mechanism of action, the effects of pd, cf …

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tem. - possess a clinical formulation in latin pedagogical objectives: consider clinical pharmacology of anti-inflammatory drugs. consider the mechanism of action of different groups of drugs demonstrate patients taking nsaids. teach students to monitor the effectiveness and safety of nsaids. teach students to evaluate the side effects of nsaids and when they occur korregirovat learning outcomes: students will know: mechanism of action, the effects of pd, fc parameters nsaids, nsaids results interactions with other drugs, the side effects of nsaids, their prevention and treatment. select the dosing regimen of nsaids on the basis of knowledge farmakokiniticheskih and pharmacodynamic parameters, the severity of the patient's condition and the functional state of metabolism and elimination in rheumatic patients. evaluate the effectiveness of the therapy. to be able to efficiently combine nsaids with each other and with other drugs. be able to predict the possible side effects and to identify ways to correct …

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k; 1.3. introduces the evaluation criteria; listen, write. clarify, ask questions 2-stage 30 minutes 5 minutes 40 minutes 40 minutes 5 minutes 2.1. enables knowledge through a quiz / question-answer / brainstorming. 2.2.made protocol in daily actions on the organization of the learning process and the structure of the corresponding plan of practical classes ("a student in the spotlight") 2.3. break 2.3. explains the operation with clusters and conceptual tables and shared students into groups 2.4. gives explanations to work with illustrative tools (tests and situational tasks, models, computer programs) in intended for the development of the theme 2.5. break answer record work in groups, etc. are 3-stage 40 minutes 40 minutes 20 minutes 20 minutes 3.1. organize the implementation of practical skills 3.2. an opinion on the case studies, draws students' attention to the importance of this topic in their future activities 3.3. assesses the group makes the analysis …

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d use of nonsteroidal anti-inflammatory drugs (nsaids) may cause ulcerative lesions of the gastrointestinal tract, causing complications and sometimes death of the patient from them. 2. interdisciplinary and intrasubject communications . teaching this subject is based on the students' knowledge of physiology, pathophysiology of musculoskeletal, cardiovascular, propaedeutics internal medicine, rheumatology, internal medicine, clinical pharmacology of non-steroidal anti-inflammatory drugs. acquired during the course knowledge will be used during the passage of therapy hirurugii, ausherstvo and gynecology for the preparation of gps. 1. the content of classes 1. introduction. 2. the theoretical part 3. the practical part (practical skills) 4. the analytical part (organizer, test and case studies) 3.1. the theoretical part nonsteroidal anti-inflammatory drugs (nsaids) are a group of drugs that are widely used in clinical practice, and many of them can be bought without a prescription. most "popular" nsaids because they have anti-inflammatory, analgesic and antipyretic effects and bring relief …

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ivity and chemical structure nsaids with a pronounced anti-inflammatory activity acids salicylates acetylsalicylic acid (aspirin) diflunisal lizinmonoatsetilsalitsilat pyrazolidines phenylbutazone indoleacetic acid derivatives indomethacin sulindac etodolac phenyllacetic acid derivatives diclofenac oxicams piroxicam tenoxicam lornoxicam meloxicam propionic acid derivatives ibuprufen naproxen flurbiprofen ketoprofen tiaprofenic acid non-acid derivatives alkanones nabumetone sulfonamide derivatives of nimesulide celecoxib rofecoxib nsaids antiinflammatory activity with weak anthranilic acid derivatives mefenamic acid etofenamate pyrazolones metamizol aminophenazone propyphenazone para-aminophenol derivatives phenacetin paracetamol geteroariluksusnoy acid derivatives ketorolac pharmacodynamics the main and common element of the mechanism of action of nsaids is inhibition of synthesis of prostaglandins (pgs) from arachidonic acid by inhibiting the enzyme cyclooxygenase (pg-synthetase) .pg have diverse biological activity: a) are mediators of the inflammatory reaction causes a local vasodilatation, edema, exudation, leukocyte migration and other effects (mostly pg-e2 and pg-i2); 6) receptors are sensitized to pain mediators (histamine, bradykinin) and mechanical stress, lowering the pain threshold; c) increase …

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subject number 8: "clinical pharmacology of non-steroidal anti-inflammatory drugs and immunomodulators" technology training (practical training) time: 270 minutes number of students: 8-9 the structure of the training session 6:00 practical lesson the structure of the lesson 1. introduction. 2. the theoretical part 3. the practical part (practical skills) 4. the analytical part (organizer, test and case studies) the purpose of the lesson: to teach students the knowledge of basic principles and umeneniyu individual selection of effective and safe nsaid with the pharmacodynamics, pharmacokinetics, side effects, and features action and its dependence on various factors (pregnancy, age, functional state of the metabolism and elimination). the student should know: -group drugs included in the st...

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