pharmacokinetic parameters of h2 blockers histamine receptors

handouts: pharmacokinetic parameters of h2 blockers histamine receptors indicator cimetidine ranitidine famotidine nizatidine i- generation ii- generation iii- generation iv- generation average initial dose, mg 400 150 40 150 bioavailability,% 70 50 40 communication with the plasma proteins,% 15-26 20 15-22 35 т1/2, h 1,9 2,6 3,7 total clearance, liters / h 80 40 1 90 is subjected to metabolism in the liver excretion in the urine in unchanged form,% 80 70 72 a large number of content time effective dose august 4 hour 4 8 side effects of antacids and adsorbents № any side effects 1 secondary hypersecretion of hydrochloric acid sodium hydrogencarbonate, calcium carbonate, magnesium carbonate 2 alkalosis sodium bicarbonate 3 fluid retention increased blood pressure, sodium bicarbonate …

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