pharmacokinetic parameters of nsaids

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theme №8. handout: pharmacokinetic parameters of nsaids inn dose, g / day absorbability bioavailability metabolism т1/2 elimination acetylsalicylic acid 3-4 80% upper small intestine. depends on the ph. food slows absorption. depends on the suction, typically 70% within the first hour of 90% of the drug is subjected to metabolism 0,5 to 80% by kidney (10-60% unchanged), 20% in the lungs and gi phenylbutazone phenylbutazone cream 0,6 90% 85-90 90% decrease with prolonged use of 95% is metabolized in the liver by 24 70% of the kidneys (5% unchanged), 30% in the form of metabolites in the gastrointestinal tract indomethacin 0,1-0,15 100% 96-98 % at intake, 85% when administered per / rektum 80% is metabolized in the liver 4-9 70% through the kidneys (20% unchanged), 30% through the digestive tract in the form of metabolites ibuprofen ibufen ibufen d (table. ointment) 0,6-1,2 95-100 food delays absorption% 95-100% 90% metabolized in …

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stomach and 12 p., bowel, bleeding from the gastrointestinal tract, perforation, esophagitis, pancreatitis, diarrhea disorders 8 endocrine system growth retardation and puberty in children, secondary adrenal insufficiency, secondary amenorrhea, steroid diabetes, latent manifestation of latent diabetes diabetning 9 ссс arterial hypertension, myocardial 10 water-electrolyte balance sodium and water retention, hypokalemia, edema, hyperosmolar coma 11 immune system activation of tuberculosis and other infections comparative activity of gcs drug name equivalent dose corticosteroids mineralkortikoidnaya mgsch activity т1/2 in the plasma, min in the tissues short-acting hydrocortisone cortisone 20 25 1 0,8 1 1 90 30 0,5 0,5 medium-long-acting prednisolone prednisone methylprednisolone 5 5 4 4 4 5 0,8 0,8 0,5 200 60 200 0,5-1,5 0,5-1,5 0,5-1,5 long-acting triamcinolone dexamethasone betamethasone 4 0,75 0,75 5 30 30 - >200 >200 >200 1-2 1,5-3 1,5-3 image4.png image1.png image2.png image3.png

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theme №8. handout: pharmacokinetic parameters of nsaids inn dose, g / day absorbability bioavailability metabolism т1/2 elimination acetylsalicylic acid 3-4 80% upper small intestine. depends on the ph. food slows absorption. depends on the suction, typically 70% within the first hour of 90% of the drug is subjected to metabolism 0,5 to 80% by kidney (10-60% unchanged), 20% in the lungs and gi phenylbutazone phenylbutazone cream 0,6 90% 85-90 90% decrease with prolonged use of 95% is metabolized in the liver by 24 70% of the kidneys (5% unchanged), 30% in the form of metabolites in the gastrointestinal tract indomethacin 0,1-0,15 100% 96-98 % at intake, 85% when administered per / rektum 80% is metabolized in the liver 4-9 70% …

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