pharmacokinetic parameters of nsaids

theme №8. handout: pharmacokinetic parameters of nsaids inn dose, g / day absorbability bioavailability metabolism т1/2 elimination acetylsalicylic acid 3-4 80% upper small intestine. depends on the ph. food slows absorption. depends on the suction, typically 70% within the first hour of 90% of the drug is subjected to metabolism 0,5 to 80% by kidney (10-60% unchanged), 20% in the lungs and gi phenylbutazone phenylbutazone cream 0,6 90% 85-90 90% decrease with prolonged use of 95% is metabolized in the liver by 24 70% of the kidneys (5% unchanged), 30% in the form of metabolites in the gastrointestinal tract indomethacin 0,1-0,15 100% 96-98 % at intake, 85% when administered per / rektum 80% is metabolized in the liver 4-9 70% …

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