educational-methodical recommendation "clinical and pharmacological approaches to rational prescribing anti-inflammatory drugs and immunomodulators"

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ministry of health of the republic of uzbekistan tashkent medical academy department of clinical pharmacology case - technology "clinical and pharmacological approaches to rational prescribing anti-inflammatory drugs and immunomodulators" educational-methodical recommendation (case - step) is designed for teachers and students of vi-year medical institutions educational abstract the subject: "clinical pharmacology" topic: "clinical and pharmacological approaches to rational prescribing anti-inflammatory drugs and immunomodulators the purpose of this case: giving students the choice of range of drugs shown in this disease based on the etiology and pathogenesis of the disease, the mechanism of action of drugs. learn the definition of the route of administration, dosage regimen of drugs according to the severity, activity and inflammatory phase, the patient's age, the pharmacokinetic characteristics of drugs. learning dosing regimen of drugs depending on the state of depleting.planning the duration of the course of therapy, the choice of criteria and deadlines for assessing the efficacy …

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ning the problem and its solution; for the successful solution of this case study, students must master in advance the following knowledge and skills: • the classification of nsaids and immunomodulators • farmakologicheskme effects of nsaids. • side effects of nsaids • indications and contraindications when using nsaids and corticosteroids • methods of efficacy and safety of nsaids and corticosteroids • prevention of nsaid side effects and their correction • the rational combination of nsaids with each other and with other drugs this case reflects the real situation in terms of primary care. sources of information of the case: 1. the basic literature: 1.kukes v.g..klinicheskaya pharmacology. . m., 2004.936 b. 2. clinic pharmacology mamadov ym t .: 2003 698 b. 3. clinic pharmacology mavlyanov ir t .: 2010 740 b. 4. mamadovyu.m. klinikfarmakologiya.t., 2010. 696 b 5. therapeutic handbook washington university. ed. m. woodley and a. whelan, trans. from english, …

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agents to suppress inflammation different unspecific factors. these include non-steroidal anti-inflammatory drugs (nsaids) and steroids (glucocorticoids - cc). the second group (ii) are basic, long-acting drugs with immunomodulating effect. they are directly or indirectly act on the main immune links of the pathological process and can change it for. on the one hand the choice of drug is made in view of its effectiveness and predicted pd, on the other hand - particularly complex pathological process. thus it is necessary to take into account some of the provisions. efficacy designated nsaids evaluated in inflammatory syndrome for 1-2 weeks. in addition to laboratory tests (determination of erythrocyte sedimentation rate, white blood cell count, acute-phase samples, c-reactive protein, and others.) some swelling index area of the joint; compressive force brushes; time during which the patient undergoes a certain distance (in the defeat of leg joints); test keitel and others. if the treatment …

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sicular breathing, pulse 92 in 1 min, blood pressure 110/70 mm hg, abdomen is soft with / without painful swelling not. in obўem blood test: hemoglobin 96 g / l, erith-3,6h1012 / lake 1 - 6.2 x 109/1. esr-46 mm / h, haptoglobin-1400, aso 250 u ,, rheumatoid factor (-), c-reactive protein 3+. 1. the most likely diagnosis? 2. what group of drugs are the drugs of choice for this disease? 3. what refers to indicators to monitor the effectiveness of nsaids with ankylosing spondylitis? ii. methodical instructions to the student issue: pharmacological treatment for the disease spondylitis. subproblems: - selection of the most effective and safe drug or combination of drugs, depending on the severity of the disease -pobochnye effects of nsaids and methods of their correction -set the dosing regimen of nsaids when choosing a drug in a particular clinical situation must be taken into account the severity …

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selective cox-2 inhibitors (movalis, nimesil). when selecting products also taken into account the ability to cause pd from the gastrointestinal tract, including the formation of ulcers. distinguish drugs, the application of which the likelihood of ulcerogenic pd: 1) low (in descending order of risk - ibuprofen>diclofenac>analginum); 2) moderate (piroxicam> naproxen>phenylbutazone), and 3) high (ack> indomethacin). selective cox-2 inhibitors (movalis, nimesil, meloxicam, etodalak), having a high anti-inflammatory activity, is well tolerated and minimal effect on gastroprotective prostaglandins, both in the short and long course of treatment. clinical studies have shown a very low frequency of erosive and ulcerative lesions of the gastroduodenal mucosa with their use (0.3-0.7% vs. 15-20% when receiving the "old" nsaids). given the likelihood of developing pd from the gastrointestinal tract, the nsaid is not advisable to assign patients with concomitant erosive and ulcerative disorders of the stomach and duodenum, or give preference to selective cox-2 inhibitors or …

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ministry of health of the republic of uzbekistan tashkent medical academy department of clinical pharmacology case - technology "clinical and pharmacological approaches to rational prescribing anti-inflammatory drugs and immunomodulators" educational-methodical recommendation (case - step) is designed for teachers and students of vi-year medical institutions educational abstract the subject: "clinical pharmacology" topic: "clinical and pharmacological approaches to rational prescribing anti-inflammatory drugs and immunomodulators the purpose of this case: giving students the choice of range of drugs shown in this disease based on the etiology and pathogenesis of the disease, the mechanism of action of drugs. learn the definition of the route of administration, dosage regimen of drugs accor...

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