educational-methodical recommendation (a case-study) "clinical pharmacology of medicines influencing on hemostasia system"

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uzbekistan republic health ministry the tashkent medical academy chair of clinical pharmacology case-technology on a theme: «clinical pharmacology of medicines influencing on hemostasia system» the educational-methodical recommendation (a case-study) is intended for teachers and 5th courses students of medical high schools ташкент – 2013 the pedagogical summary subject: « clinical pharmacology » theme: «clinical pharmacology of medicines, influencing on hemostasia system» the purpose of the given case: to learn students to knowledge of clinical pharmacology of medicines, influencing on hemostasia, to train students in knowledge of main principles and skills of cardiotonic agents individual selection with the account of pharmacodinamicsки, pharmacokinetics, collateral action, and also features of action and from various factors. planned educational results – by the results of work with a case students get skills: · modern classification of medicines, influencing on hemostasia · the action mechanism of medicines, influencing on hemostasia. · pharmacodinamic effects and pharmacokinetic parameters …

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of clinical compaunding. the given case reflects a real situation in the conditions of a primary link sources of the information of a case 1. v.g.kukes. clinical pharmacology. м, 2008. 2. j.b.belousov. clinical pharmacology and pharmacotherapy. м, 2003. 3. i.r.mavljanov. clinics pharmacology. tashkent, 2010 4. j.m.mamadov. clinics pharmacology. tashkent, 2006. 5. bertram katsung. basic and clinical pharmacology. м, 2001. 6. r.k. makhkamova. clinical pharmacology of medicines, influencing on hemostasia, 2000. the case characteristic according to typological signs the given case concerns a room, subject category. it is volumed, structured. it is a case-question. by the didactic purposes a case is training, thinking stimulating in a real situation in the conditions of rmp and cmp. the case can be used on disciplines: clinical pharmacology, therapy. i case «clinical pharmacology of medicines, influencing on hemostasia system» introduction the term "hemostasis" designate all processes directed on preservation of blood in the bloodstream, prevention …

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nadroparinum, parnaparinum, rheumaparinum, enoxaparinum), their derivatives and antithrombin iii. mechanism of action and main pharmacodynamic effects. sodium heparin blocks almost all factors of a blood coagulation connected with serine protease. possesses the expressed antithrombin activity, breaks transition of a prothrombin to thrombin and opresses the activity of thrombin, reduces aggregation of platelets, moderately increases fibrinolitic properties of blood. to positive properties of a heparin also belong the anti-atherosclerotic (due to depression of a cholesterin and beta lipoproteins in serum), analgetory, antiinflammatory, antiallergic, immunosuppressive, hypoglycemic (potentiation of insulin effect and other hypoglycemic preparations), diuretic and potassium-sparing effects. antiinflammatory, antiallergic, immunosupressive effects are bound to ability of a heparin to suppress hyaluronidasum, to slow down reaction an antigen antibody, to show opposing action to histaminum, a serotonin, aktg and aldosteronum. the heparin reduces vascular resistance due to expansion of resistive vessels, eliminates a spastic stricture of coronary arteries. pharmacokinetics. the heparin is …

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f clottages and embolisms at patients with prostheses of heart valves, stenocardia, a myocardial infarction. · initial stages of a dvs syndrome. · prophylaxis and treatment of the tromboembolic diseases at pregnant women (a choice agent). side effects: · hemorrhagic reactions. the risk of a hemorrhage is enlarged at intermittent introduction in high doses, i.v. introduction, of long, more than 2-3 weeks, application. · allergic reactions. are observed seldom, and usually have no difficult character, are shown by a headache, arthralgias, mialgiya, dermal changes on 3-7 day of treatment, at repeated purposes of a preparation after 5-7 day of applications. · "rebound" syndrome (repeated clottages). sudden cancellation of g. promotes. · reversible allopecia. the risk factors of development of a heparin side effect are: the diabetes mellitus with the expressed angiopatiya, a sepsis, a bacterial endocarditis, the expressed cerebral atherosclerosis with frequent disturbances of a cerebral circulation, severe damages of …

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ofarin, phencarolum, syncumarum, acenocoumarolum, etc.) and derivatives of an indandion (phenilinum, omephinum, etc.) belong to indirect anticoagulants (iac). the action mechanism and main pharmacodynamic effects. synthesis of ii, vii, ix and x factors of a fibrillation is carried out by γ-carboxylating in which vitamin k participates, turning thus into an inactive, epoxy form. in addition there is an enzyme epoxide reductase under the influence of which epoxide restoration again in active vitamin k is carried out. if to block this enzyme, there will be no formation of the active vitamin k necessary for synthesis of the specified fibrillation factors. the short of the mechanism of indirect anticoagulants effects consists in it. anticoagulative action of indirect anticoagulants comes not at once, but develops through certain time after removal of earlier formed k-dependent factors of a fibrillation. pharmacokinetics. being lipophilic preparations the indirect anticoagulants well absorbed in a gastrointestinal tract (90-95%). are …

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uzbekistan republic health ministry the tashkent medical academy chair of clinical pharmacology case-technology on a theme: «clinical pharmacology of medicines influencing on hemostasia system» the educational-methodical recommendation (a case-study) is intended for teachers and 5th courses students of medical high schools ташкент – 2013 the pedagogical summary subject: « clinical pharmacology » theme: «clinical pharmacology of medicines, influencing on hemostasia system» the purpose of the given case: to learn students to knowledge of clinical pharmacology of medicines, influencing on hemostasia, to train students in knowledge of main principles and skills of cardiotonic agents individual selection with the account of pharmacodinamicsки, pharmacokinetics, collateral action, and also featu...

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