carcinoma cervix

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carcinoma cervix carcinoma cervix 509-b guruh talabasi almatova sevarabonu risk factors for carcinoma cervix early age at intercourse:<16 2 times repeated / frequent births multiple sexual partners hpv infections (type 16 & 18 highly oncogenic) low socio-economic status smoking:2-gen and immunosupresion natural history of hpv infection schiffman m, castle p. n engl j med 2005, 353:2101-2104 * site ectocervix 80% endocervix 20% gross lesion occult proliferative : friable growth ulcerative : erodes the cervix to form an irregular crater infiltrative : expands the cervix histopathology squamous cell carcinoma (80-90%) large cell keratinizing large cell non-keratinizing small cell adenocarcinoma (10-20%) endocervical clear cell adeno-squamous adeno-acanthoma spread direct vagina uterus parametrium lymphatic primary nodes obturator internal & external iliac sacral secondary nodes common iliac para-aortic inguinal haematogenous lungs liver bone staging of invasive disease stage i : carcinoma confined to the cervix (extension to the corpus should be disregarded) stage ia : …

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t coital inter-menstrual post-menopausal abnormal discharge blood stained dirty foul smelling late symptoms pelvic pain urinary symptoms rectal symptoms diagnosis of carcinoma cervix signs abnormal area / growth on cervix induration friability bleeding on touch fixity confirmation of diagnosis diagnosis is confirmed by histopathological examination of the biopsy sample differential diagnosis cause of death uraemia haemorrhage sepsis prevention of carcinoma cervix health education avoid early marriage avoid early intercourse avoid promiscuity proper hygiene use of barrier contraception screening programs screening for pre-malignant lesions screening for early diagnosis investigations biopsy intravenous urography abdominal ultrasonography cystoscopy examination under anaesthesia (eua) ct / mri treatment surgery: radiotherapy combined chemo-radiation 5 year survival stage i 70% stage ii 51% stage iii 33% stage iv 17% thank you for attention

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carcinoma cervix carcinoma cervix 509-b guruh talabasi almatova sevarabonu risk factors for carcinoma cervix early age at intercourse:<16 2 times repeated / frequent births multiple sexual partners hpv infections (type 16 & 18 highly oncogenic) low socio-economic status smoking:2-gen and immunosupresion natural history of hpv infection schiffman m, castle p. n engl j med 2005, 353:2101-2104 * site ectocervix 80% endocervix 20% gross lesion occult proliferative : friable growth ulcerative : erodes the cervix to form an irregular crater infiltrative : expands the cervix histopathology squamous cell carcinoma (80-90%) large cell keratinizing large cell non-keratinizing small cell adenocarcinoma (10-20%) endocervical clear cell adeno-squamous adeno-acanthoma spread direct vagina uterus paramet...

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