liver cirrhosis

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powerpoint presentation liver cirrhosis numonjonov muhammadsafo 1. treatment and management 2. understanding liver cirrhosis 3. causes, symptoms, and diagnosis plan: pathophysiology of cirrhosis hepatocyte necrosis initiates inflammation and activation of hepatic stellate cells. these activated cells deposit excess collagen, leading to fibrosis, disrupting normal liver architecture over a 5-10 year period. impaired hepatic detoxification leads to elevated ammonia levels exceeding 50-100 µmol/l causing hepatic encephalopathy. this affects brain function due to its neurotoxic effect, further compromising the body's balance. elevated portal pressure above 10 mmhg triggers varices and ascites. reduced hepatic blood flow of about 80% stimulates neoangiogenesis, exacerbating portal hypertension via increased splanchnic blood flow. what is liver cirrhosis? what is liver cirrhosis? it's a chronic condition where healthy liver tissue is replaced by scar tissue, known as fibrosis. this progressive damage happens over months or years, impacting the liver's essential functions. cirrhosis distorts the liver's normal structure, forming …

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mortality rate of 10-30%. treatment options and management treatment for ascites involves diuretics like spironolactone and furosemide, typically starting at 100 mg and 40 mg respectively. paracentesis removes fluid but carries a risk of infection. treatment options and management beta-blockers, such as propranolol, with a target heart rate of 55-60 bpm, are used to prevent variceal bleeding. endoscopic band ligation eradicates varices during the acute phase. prevention strategies get vaccinated against hepatitis b and c, as these viral infections cause around 60-70% of cirrhosis cases. protect yourself by receiving the complete 3-dose hepatitis b vaccine series. avoid risky alcohol consumption by adhering to guidelines, with no more than 1 drink per day for women and 2 for men, minimizing the 50% cirrhosis risk increase associated with heavy drinking. maintain a healthy weight through diet and exercise. obesity increases the risk of nonalcoholic fatty liver disease (nafld), which can progress to …

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formation causes and risk factors nonalcoholic fatty liver disease (nafld), affecting 20-30% of adults, is rising as a major cause. obesity, type 2 diabetes, and high cholesterol are significant risk factors for nafld progression. excessive alcohol consumption over 10-12 years increases the risk substantially. drinking more than 2-3 standard drinks daily for men and 1-2 for women elevates the risk significantly. chronic hepatitis b or c viral infections account for approximately 50% of cirrhosis cases globally. long-term inflammation damages liver cells, leading to fibrosis and eventually, cirrhosis. diagnosis and evaluation fibroscan, a non-invasive test using transient elastography, quantifies liver stiffness by measuring shear wave velocity in kilopascals (kpa), helping assess the degree of fibrosis; a kpa score over 12.5 suggests cirrhosis. a liver biopsy, although invasive, remains the gold standard; histological examination allows for definitive diagnosis and grading of fibrosis, using systems like the metavir scoring system (f0-f4). laboratory tests, …

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powerpoint presentation liver cirrhosis numonjonov muhammadsafo 1. treatment and management 2. understanding liver cirrhosis 3. causes, symptoms, and diagnosis plan: pathophysiology of cirrhosis hepatocyte necrosis initiates inflammation and activation of hepatic stellate cells. these activated cells deposit excess collagen, leading to fibrosis, disrupting normal liver architecture over a 5-10 year period. impaired hepatic detoxification leads to elevated ammonia levels exceeding 50-100 µmol/l causing hepatic encephalopathy. this affects brain function due to its neurotoxic effect, further compromising the body's balance. elevated portal pressure above 10 mmhg triggers varices and ascites. reduced hepatic blood flow of about 80% stimulates neoangiogenesis, exacerbating portal hypertension ...

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