neurodegeneration as a complication of nonalcoholic fatty liver disease (review article)

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central asian journal of medicine journals.tma.uz 12 2023#2 neurodegeneration as a complication of nonalcoholic fatty liver disease (review article) feruza kh. inoyatova1, mashkhura i. abdullayeva2 1 doctor of medicine, professor of the department of medical and biological-chemistry of the tashkent medical academy, tashkent, uzbekistan e-mail: inoyatova49@mail.ru 2 dsc student of the department of medical and biological-chemistry of the tashkent medical academy, tashkent, uzbekistan e-mail: mashhura.ikromjonovna@mail.ru abstract non-alcoholic fatty liver disease (nafld) is now characterized as the hepatic manifestation of metabolic syndrome, is the leading cause of liver cirrhosis and currently affects a quarter of the world's population. a number of recent studies have focused on the prevalence of neurodegeneration, including dementia and cognitive impairment in nafld. various risk factors, including insulin resistance, cerebrovascular dysfunction, intestinal dysbiosis, hyperammonemia, neuroinflammation and etc. given the prevalence of nafld, its negative impact on cognitive function is a medical problem with enormous social and economic …

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ance. one of the main causes of liver cirrhosis is nafld. because, nafld is characterized by the accumulation of triglycerides in the liver and can progress from simple fatty steatosis, steatohepatitis to fibrosis and eventually cirrhosis which can progress to central asian journal of medicine central asian journal of medicine journals.tma.uz 13 2023#2 hepatocellular carcinoma. although hepatic steatosis is usually reversible, approximately, one-third of patients with nafld progress to nonalcoholic steatohepatitis (nash) leading to severe cirrhosis or hepatocellular carcinoma. the mechanisms of the transition of nafld to nash are not fully known, but the role of lipotoxicity, oxidative stress and anti-inflammatory mediators in the development of this disease has been studied [19]. people's lifestyle, eating habits and genetic background play an important role in the incidence of nafld. other metabolic diseases such as type 2 diabetes, chronic kidney disease, cardiovascular diseases, and intestinal dysbiosis serve as common risk factors for …

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ociated with insulin resistance, hyperammonemia, vascular dysfunction, gut microbiota disruption, inflammation, and other features observed in patients with nafld [55]. phenotopic manifestation of nafld is associated with obesity. obesity has been shown to increase the risk of developing cognitive decline and alzheimer's disease six times in adulthood and middle age. also, obesity in middle age significantly increases the risk of dementia and alzheimer's disease, unlike obesity in later life [2; 38; 57]. pathogenesis of nafld. triglycerides (tg) are the main lipid components of the liver, and their accumulation in the liver is observed due to the entry of free fatty acids (ffa) into the liver or an increase in the synthesis of fatty acids from acetyl coenzyme a in the liver itself. the pathogenesis of nafld is multifactorial, but insulin resistance and obesity are the main factors in the development of this disease. the safest way to store ffas is …

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on (lpo) and the development of apoptotic and necrotic processes in hepatocytes. if inflammation and liver damage are not observed, it does not progress to the next stage of steatosis, activation of inflammatory cytokines and oxidative stress under the influence of free fatty acids. originates. hepatic accumulation of eik and cholesterol leads to mitochondrial dysfunction and er stress, resulting in tumor necrosis factor-α (tnf-α)-mediated liver injury and accumulation of reactive oxygen species (ros). the gut-liver axis is also affected by food, resulting in microbiota dysbiosis and production of inflammatory cytokines. multiple receptors (mrs) in the intestinal epithelium can respond to dietary lipids, influencing systemic inflammation and insulin resistance. adipose tissue is able to produce several mediators, such as leptin, interleukin 6 (il-6) and tnf-α, which are responsible for the interaction between liver and adipose tissue in the pathogenesis of nafld. 15-20% of nafld patients develop nash due to the development …

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oholic fatty liver disease is becoming increasingly important in the pathogenesis of neurodegeneration and is one of the risk factors for the development of mild cognitive impairment and dementia. dementia is a prevalent disease worldwide, with approximately 50 million people affected by dementia and this number expected to increase annually [ 39 ]. central asian journal of medicine journals.tma.uz 15 2023#2 according to the world health organization, the number of people with dementia will reach 82 and 152 million in 2030 and 2050 [21]. in addition, as the world's population lives longer, alzheimer's disease and dementia are predicted to be a major global health problem in an aging world population. it is characterized by mental and cognitive degeneration, which leads to memory loss and cognitive impairment. there are the following types of dementia: alzheimer's dementia (ad), diabetes-related dementia, and vascular dementia. there is evidence that all types of dementia are …

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central asian journal of medicine journals.tma.uz 12 2023#2 neurodegeneration as a complication of nonalcoholic fatty liver disease (review article) feruza kh. inoyatova1, mashkhura i. abdullayeva2 1 doctor of medicine, professor of the department of medical and biological-chemistry of the tashkent medical academy, tashkent, uzbekistan e-mail: inoyatova49@mail.ru 2 dsc student of the department of medical and biological-chemistry of the tashkent medical academy, tashkent, uzbekistan e-mail: mashhura.ikromjonovna@mail.ru abstract non-alcoholic fatty liver disease (nafld) is now characterized as the hepatic manifestation of metabolic syndrome, is the leading cause of liver cirrhosis and currently affects a quarter of the world's population. a number of recent studies have focused on the prev...

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