bioximiya soedinitelnoy tkani

PPT 61 pages 2.3 MB Free download

61 pages

FaylHub.uz

Download via Telegram

Size 2.3 MB

File type PPT

Pages 61

Updated Dec 2025

Page preview (5 pages)

Scroll down 👇

1 / 61

voenno-meditsinskaya akademiya kafedra klinicheskoy bioximii i laboratornoy diagnostiki kafedra fundamegntalnix meditsinskix distsiplin prakticheskoe zanyatie №7 «bioximiya soedinitelnoy tkani.» tashkentskiy mejdunarodniy universitet kimyo kimyo international university in tashkent plan klassifikatsiya soedinitelnoy tkani funktsii soedinitelnoy tkani. ximicheskiy sostav soedinitelnoy tkani morfologicheskaya i bioximicheskaya xarakteristika komponentov tkani. osobennosti aminokislotnogo sostava, i fiziko-ximicheskix svoystv osnovnix strukturnix belkov. 2. biosintez kollagena, obrazovanie fibrillyarnix struktur. 3. glikozaminoglikani osnovnogo veshestva, stroenie, biosintez, biologicheskaya rol, produkti raspada.. 4. spetsificheskie cherti metabolizma soedinitelnoy tkani, gormonalnaya regulyatsiya. 5. ponyatie o kollagenozax i mukopolisaxaridozax. ximicheskiy sostav kostey. 6. bioximicheskie testi v diagnostike zabolevaniy soedinitelnoy tkani klassifikatsiya soedinitelnoy tkani 1. voloknistaya tkan: a). rixlaya neoformlennaya (obrazuet stromu mnogix organov, adventitsialnaya obolochka sosudov, obrazuet sobstvennuyu plastinku slizistix obolochek, podslizistuyu osnovu, raspolagaetsya mejdu mishechnimi kletkami i voloknami); b). plotnaya neoformlennaya ( setchatiy sloy dermi, nadkostnitsa, nadxryashnitsa); v). plotnaya oformlennaya (suxojiliya, svyazki, kapsuli, fastsii, fibroznie membrani); 2. skeletnie tkani: a). xryashevaya tkan (3 vida: gialinoviy, …

2 / 61

mozg); 4. krov funktsii soedinitelnoy tkani opornaya — kosti, xryashi, svyazki i suxojiliya; transportnaya — krov i limfa; zashitnaya — kletkami krovi virabativayutsya antitela, osushestvlyaetsya fagotsitoz; oni uchastvuyut v zajivlenii ran i regeneratsii organov. jirovaya, skeletnaya, xryashevaya tkan zashishayut vnutrennie organi ot mexanicheskogo povrejdeniya. jirovaya tkan – ot pereoxlajdeniya; krovetvornaya — limfaticheskie uzli, selezenka, krasniy kostniy mozg; zapasayushaya – jirovaya tkan zapasaet tg, skeletnaya tkan i zubi – kaltsiy, magniy, fosfor, natriy, krov v belkax plazmi soderjit zapas aminokislot. regulyatornaya – kletkami soedinitelnoy tkani sinteziruyutsya bav (bolee 100), kotorie reguliruyut obmen veshestv (leptin), razvitie immunnix, allergicheskix reaktsiy (prostaglandini, gistamin, serotonin), kletochnoe delenie, differentsirovku tkaney (somatomedini, faktori rosta i ingibirovaniya fibroblastov, mitoticheskiy i ingibiruyushiy proliferatsiyu faktor). mejkletochniy matriks (bazalnaya membrana) obespechivaet razvitie organov i tkaney, uchastvuet v protsessax regeneratsii. kak i lyubaya tkan, soedinitelnaya tkan sostoit iz kletok i mejkletochnogo matriksa. v otlichie ot drugix tkaney, v ney, kak pravilo, soderjitsya …

3 / 61

nadmolekulyarniy kompleks, obrazovanniy slojnoy setyu svyazannix mejdu soboy makromolekul. funktsiya mejkletochnogo matriksa obrazuet karkas organov i tkaney; yavlyaetsya universalnim «biologicheskim» kleem; uchastvuet v regulyatsii vodno-solevogo obmena; obrazuet visokospetsializirovannie strukturi (kosti, zubi, xryashi, suxojiliya, bazalnie membrani). okrujaya kletki, vliyaet na ix prikreplenie, razvitie, proliferatsiyu, organizatsiyu i metabolizm. ximicheskiy sostav mejkletochnogo matriksa 1). kollagenovie i elastinovie volokna. oni pridayut tkani mexanicheskuyu prochnost, prepyatstvuya ee rastyajeniyu; 2). amorfnoe veshestvo v vide gag i proteoglikanov. ono uderjivaet vodu i mineralnie veshestva, prepyatstvuet sdavlivaniyu tkani; 3). nekollagenovie strukturnie belki - fibronektin, laminin, tenastsin, osteonektin i dr. krome togo, v mejkletochnom matrikse mojet prisutstvovat 4). mineralniy komponent - v kostyax i zubax: gidroksiapatit, fosfati kaltsiya, magniya i t.d. on pridaet mexanicheskuyu prochnost kostyam, zubam, sozdaet zapas v organizme kaltsiya, magniya, natriya, fosfora. ximicheskiy sostav soedinitelnoy tkani voda (63%.) plotnie veshestva (37%), iz nix: kollagen 85% elastin 4,4% retikulin 0,5% albumini i globulini 0,6% glikozoaminoglikani (gag) 3,5 …

4 / 61

olisaxaridov, neobxodimix dlya postroeniya mejkletochnogo matriksa regulyatsiya obmena soedinitelnoy tkani sintez kollagena i gag proteoglikanov glyukokortikoidi starenie organizma mineralokortikoidi androgeni (testosteron) somatomedin – vklyuchenie sulfatov v gag (fafs) starenie soedinitelnoy tkani umenshenie soderjaniya n2o i otnosheniya osnovnoe veshestvo/volokna snijenie soderjaniya gialuronovoy kisloti izmenenie sootnoshenie otdelnix glikanov svoystva 1. visokaya elastichnost (elastin), 2. visokaya prochnost (kollagen), 3. voloknistost, 4. ploxaya rastvorimost v vode, 5. visokaya ustoychivost k denaturatsii, 6. ploxaya perevarivaemost v jkt, 7. nizkaya antigennost, 8.nizkaya biologicheskaya tsennost iz-za ogranichennogo aminokislotnogo sostava. belki soedinitelnoy tkani kollagen — fibrillyarniy belok, osnovnoy komponent mejkletochnogo matriksa. obladaet ogromnoy prochnostyu i prakticheski ne rastyajim (prochnee stalnoy provoloki togo je secheniya, on mojet viderjivat nagruzku v 10000 raz bolshuyu sobstvennogo vesa). eto samiy rasprostranenniy belok organizma, na nego prixoditsya ot 25 do 33% obshego kolichestva belka v organizme, t.e. 6% massi tela. okolo 50% vsex kollagenovix belkov soderjitsya v tkanyax skeleta, okolo 40% — v …

5 / 61

a drug s drugom v pravozakruchennuyu superspiral tropokollagena. ona stabiliziruetsya vodorodnimi svyazyami, radikali ak napravleni naruju. molekula tropokollagena fibrilli i volokna kollagena molekula prokollagena ustroena takje kak i tropokollagena, no na ee kontsax naxodyatsya s- i n-propeptidi, obrazuyushie globuli. n-kontsevoy propeptid sostoit iz 100ak, s-kontsevoy propeptid – iz 250ak. s- i n-propeptidi soderjat tsistein, kotoriy cherez disulfidnie mostiki obrazuet globulyarnuyu strukturu. vidi kollagena izvestno 19 tipov kollagena, kotorie otlichayutsya po pervichnoy strukture tsepey, funktsiyam i lokalizatsii v organizme. 95% vsego kollagena v organizme cheloveka sostavlyayut kollageni i, ii i iii tipov. i - suxojiliy, svyazok, ii -xryashey, iii - krovenosnix sosudov, koji, kishechnika iv - bazalnix membran. sintez kollagena 1. na polisomax epr sinteziruyutsya polipeptidnie prepro-α-tsepi kollagena. 1000 100 100 250 signalniy peptid n-konets α-tsep s-peptid sintez 1000 100 100 250 signalniy peptid n-konets α-tsep s-peptid 2. v polosti epr pri otsheplenii signalnogo peptida prepro-α-tsepi prevrashayutsya v pro-α-tsepi. peptidaza pro-α-tsep …

Want to read more?

Download all 61 pages for free via Telegram.

Download full file

About "bioximiya soedinitelnoy tkani"

voenno-meditsinskaya akademiya kafedra klinicheskoy bioximii i laboratornoy diagnostiki kafedra fundamegntalnix meditsinskix distsiplin prakticheskoe zanyatie №7 «bioximiya soedinitelnoy tkani.» tashkentskiy mejdunarodniy universitet kimyo kimyo international university in tashkent plan klassifikatsiya soedinitelnoy tkani funktsii soedinitelnoy tkani. ximicheskiy sostav soedinitelnoy tkani morfologicheskaya i bioximicheskaya xarakteristika komponentov tkani. osobennosti aminokislotnogo sostava, i fiziko-ximicheskix svoystv osnovnix strukturnix belkov. 2. biosintez kollagena, obrazovanie fibrillyarnix struktur. 3. glikozaminoglikani osnovnogo veshestva, stroenie, biosintez, biologicheskaya rol, produkti raspada.. 4. spetsificheskie cherti metabolizma soedinitelnoy tkani, gormonalnaya reguly...

This file contains 61 pages in PPT format (2.3 MB). To download "bioximiya soedinitelnoy tkani", click the Telegram button on the left.

Tags: bioximiya soedinitelnoy tkani PPT 61 pages Free download Telegram