farmatsevtik kimyo 2qism

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0 ‘zbekiston respublikasi sog‘liqni saqlash vazirligi toshkent farmatsevtika instituti a.yu. ibodov, a.n. yunusxo‘jayev, q.a. ubaydullayev farmatsevtik kimyo ii qism o ‘zbekiston respublikasi oliy va o 'rta maxsus ta 'lim vazirligi farmatsevtika oliy ta'lim muassasasi talabalari uchun darslik sifatida tavsiya etgan toshkent «voris-nashriyot» 2011 o'zbekiston respublikasi davlat mustaqilligining 20 yilligiga bag'ishlanadi 35.66 1-13 ibodov, a. yu. farmatsevtik kimyo : [2 qismli] / a. yu. ibodov, a. n. yunusxo‘ja- yev, q. a. ubaydullayev ; o lzr sog'liqni saqlash vazirligi, toshkent far-matsevtika in-ti. - t . : voris, 2011. - q. ii. - 560 b. i. yunusxo'jayev, a. n. ii. ubaydullayev, q. a. bbk 35.66 taqrizchilar: udk 681 7 o.a. shabilo lov - toshkent farmatsevtika instituti ilm iy ishlar va axborot texnologiyalari bo‘yicha prorektori, kimyo fanlari dokto ri, professor, a.f. d o‘sm atov - dori vositalari va tibbiy texnika sifatini nazorat qilish bosh boshqarmasi dori vositalari sifatini nazorat qilish va stan dartlash laboratoriyasi …

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artma so‘zlar...................................................................................9 so'zboshi............................................................................................ 10 aromatik birikmalar 1-bob. fenollar xinonlar va ularning hosilalari.....................................11 1.1. fenollar (fenol, timol, rezorsin)........................................................ 11 toza fenol........................................................................................... 12 timol..................................................................................................13 rezorsin..............................................................................................13 1.2 naftaxinon hosilalari........................................................................23 vitamin k ta’siriga ega birikmalar.......................................................... 23 oksolin............................................................................................... 32 2-bob. tetrasiklinlar........................................................................... 34 3-bob. para-aminofenolning tibbiyotda qo'llanadigan hosilalari............42 4-bob. aromatik-kislotalar va ularning tibbiyotda qo'llanadigan preparatlari.................................................................. 49 4.1. benzoy va salitsil kislota. ulaming natriyli tuzlari..............................49 4.2. salitsil kislotaning amid hosilalari (salitsilamid. oksafenamid)............54 4.3. salitsil kislotaning murakkab efirlari................................................. 58 5-bob. para- va orto-aminobenzoy hamda para-aminosalitsil kislota hosilalari.................................................................................. 62 5.1. para-aminobenzoy kislota hosilalari.................................................. 63 5.2. dialkilaminoatsetanilid hosilalarining tibbiyotda ishlatiladigan preparatlari...........................................

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............................................... 73 5.3. orto-aminobenzoy va orto-aminofenilatsetat kislotalarining tibbiyotda qo'llanadigan preparatlari...................................................................... 78 5.4. para-aminosalitsil kislotaning tibbiyotda ishlatiladigan hosilalari..............................................................................................82 natriy para-aminosalitsilat, natriy-pas....................................................82 bepask............................................................................................... .‘83 6-bob. arilalkilaminlarning tibbiyotda qo'llanadigan hosilalari............ 88 efedrin gidroxlorid................................................................................88 7-bob. oksifenilalkilamin hosilalari......................................................90 buyrak usti bezi miya qavati gormonlari va ularga o‘xshash sintetik-preparatlar................................................................................ 90 m u n d arija 3 8-bob. oksifenilaminoalifatik-kislotalarning tibbiyotda ishlatiladigan hosilalari......................................................................107 9-bob. nitrofenilalkilaminlar............................................................. 110 aromatik-qator antibiotiklar.................................................................110 levomitsetin stearat.................................... ....................................... 116 eruvchan levomitsetin suksinat.............................................................118 10-bob. arilalifatik-qator oddiy efiriar............................................... 120 dimedrol............................................................................................120 gidroksizin gidroxlorid........................................................................121 11-bob. arilalifatik kislota efiriari va ularning tibbiyotda qomlanadigan preparatlari...........................

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....................... ............. 125 spazmolitin........................................................................................ 125 metatsin.............................................................................................125 tifen.................................................................................................126 amizil............................................................................................... 126 12-bob. aromatik va arilalifatik kislotalarning tarkibida yod saqlovchi hosilalari..................................................................... 134 yopanoy kislota..................................................................................135 triombrin. triombrast......................................................................... 135 tireoidin.............................................................................. -............142 triyodtironin gidroxlorid.................................................................... . 142 13-bob. benzolsulfanilamidlar va ularning hosilalari...........................148 sulfanilamid preparatlari.............. ...................................................... 148 sulfanilamid preparatlarining chinligini aniqlashda qo'llanadigan reaksiyalar..........................................................................................152 azobo'yoq hosil qilish reaksiyasi..........................................................153 galloidlash reaksiyasi.......................................................................... 154 og'ir metall tuzlari yordamida aniqlash................................................. 155 termik-parchalash usuli bo'yicha aniqlash............................................. 157 sulfanilamidlaming tarkibidagi oltingugurtni aniqlash............................. 158 sulfanilamid preparatlarining miqdorini aniqlash usuilari......................... 163 sulfanilamid preparatlarini fizikaviy va fizik-kimyoviy usullar bo'yi

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cha aniqlash................................................................................ 168 14-bob. xlorbenzolsulfamid va benzotiadiazinning tibbiyotda qomlanadigan preparatlari................................................................. 169 15-bob. benzsulfamid va sulfanilamidning diabet kasalligiga qarshi qo‘llanadigan mochevinali hosilalari........................................ 179 16-bob. benzolsulfoxloramid hosilalari............................................... 186 4 geterosiklik birikmalar 17-bob. geterosiklik birikmalarning tasniflanishi va tibbiyotda ishlatiladigan hosilalari......................................................................190 i. kislorod geteroatomi saqlagan birikmalar 18-bob. furan va uning tibbiyotda ishlatiladigan hosilalari................. 193 5-nitrofiiran hosilalari......................................................................... 194 19-bob. benzopiran hosilalari kumarin va xroman birikmalari.......... .202 4-oksikumarin qator preparatlar............................................................ 203 20-bob. xroman qator dori moddalari.............................................. .212 21-bob. feoilxroman qator preparatlar............................................. 218 flavanoidlar....................................................................................... 218 rutin............................................................................................... . 222 kversetin........................................................................................... 226 ii. azot saqlovchi geterosiklik birikmalarning hosilalari 22-bob. pirrol va pirrolizidin qator dori moddalari.............................228 pirasetam. nootropil............................................................................228 sianokobalamin (vitamin bi2).............................................................. 230 oksikobalamin...................................................................................

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0 ‘zbekiston respublikasi sog‘liqni saqlash vazirligi toshkent farmatsevtika instituti a.yu. ibodov, a.n. yunusxo‘jayev, q.a. ubaydullayev farmatsevtik kimyo ii qism o ‘zbekiston respublikasi oliy va o 'rta maxsus ta 'lim vazirligi farmatsevtika oliy ta'lim muassasasi talabalari uchun darslik sifatida tavsiya etgan toshkent «voris-nashriyot» 2011 o'zbekiston respublikasi davlat mustaqilligining 20 yilligiga bag'ishlanadi 35.66 1-13 ibodov, a. yu. farmatsevtik kimyo : [2 qismli] / a. yu. ibodov, a. n. yunusxo‘ja- yev, q. a. ubaydullayev ; o lzr sog'liqni saqlash vazirligi, toshkent far-matsevtika in-ti. - t . : voris, 2011. - q. ii. - 560 b. i. yunusxo'jayev, a. n. ii. ubaydullayev, q. a. bbk 35.66 taqrizchilar: udk 681 7 o.a. shabilo lov - toshkent farmatsevtika instituti ilm iy ishlar va ...

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