akusherlikda rezus omil

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rh disease akusherlikda rezus omil lecturer: ayupova d.k. tashkent medical academy department of obstetrics №1 rh – iso-immunization definition pathophysiology management haemolitic disease fetus prevention ta'rifi patofiziologiya olib borish xomilani gemolitik kasalligi profilaktika rh factor proteins (antigens) occurring only on surface of rbc’s rh + if proteins present rh – if proteins absent a+, a-, b+, b-, ab+, ab-, o+, o- most important for pregnancy inheritance is autosomal dominant 15% caucasian population is rh- oksil (antigen)fakatgina eritrotsitlar yuzasidagina joylashadi rh + oksil mavjud rh – oksil yuk a+, a-, b+, b-, ab+, ab-, o+, o- odaida xomiladorlik davrida muxim nasliylikning autosom dominant turi 15% xalk rh- rh disease rezus mojaro occurs during pregnancy when there is an incompatibility between the blood types of the mother and fetus xomiladorlik davrida ona va xomila koni urtasida nomutanosiblik vujudga keladi, nomenclature correct to say rh(d) + or – rh blood system has other …

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ation xomilador aelni kon guruxini eritrotsitlarga antitanachalar borligini aniklash kayta tekshiruvdan xar 6 oyda utish anti-d immunoglobulinni buyurish bilan 98.5% rezus mojaroning oldi olinadi 99.9% rezus mojaroni oldini olish uchinchi uch oylikda anti-d ni kiritish bilan erishiladi kayta tekshiruv 28 xaftada utkaziladi va anti-d 28 va 34 xaftalarda kiritiladi blood group and rbc antibody anti-k, anti-c, and anti-e screen for all pregnant women retest at least once in the 3rd trimester 98.5% of rhesus d disease is prevented by event-stimulated administration of anti-d 99.9% of rhesus d disease can be prevented by routine administration anti-d in the 3rd trimester. test at 28 weeks and then give anti-d at 28 and 34 weeks rh- iso imunization rezus izoimmunizatsiya fetomaternal hemorrhage has been documented in: 7% in the first trimester. 16% in the second trimester 29% in the third trimester risk of fetromaternal hemorrhage is increased in abruption placenta, threatened abortion, toxemia, …

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gg in 2 wks- 6 mths memory b lymphocytes activate immune response in subsequent pregnancy igg ab cross placenta and attach to fetal rbc’s cells then sequestered by macrophages in fetal spleen where they get hemolyzed fetal anemia birlamchi igm iggga 2 xaftadan 6 oygacha bulgan davrda utadi. keyingi xomladorlikda v limfotslar xotirasi faollashadi igg at platsentar tusikdan utadi va fetal eritrotsitlarni parchalaydi. xomila talokida gemolizlangan xujayralar makrofaglar tomonidan ushlanadi xomilada kamkonlik rivojlanadi rh antibodies rh - antitela there are 3 types of rh antibodies: agglutinating, blocking, hidden. rh – antitanalarning uch turi mavjud agglyutinirlovchi, bloklovchi, maxfiy. hemolytic disease of the fetus (hdf) xomilaning gemolitik kasalligi a disorder of the fetus in which fetal red blood cells are destroyed by maternal igg antibodies the igg antibodies cross the placenta and shorten red cell survival the premature red cell destruction results in disease varying from mild anemia to death in uterus …

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complain of general weakness, drowsiness, shortness of breath, a short loss of consciousness, frequent abdominal pain. in the first half of pregnancy toxicosis (50%), the threat of pregnancy termination (47%), hypotension (23%) manifest. xomiladorlar xansirash, umumiy xolsizlik, uykuchanlik, kiska muddatli xushdan ketishlar, korinda ogriklarga shikoyat kiladi erta toksikozlar (50%), xomila tushishi xavfi(47%), gipertenziya (23%). course of pregnancy xomiladorlikning kechishi in the second half of pregnancy edema (13%), pre-eclampsia (16%), anemia observed. disturbances of mother’s live function chronic fetal hypoxia xomiladorlikning ikkinchi yarmida shishlar (13%), preeklampsiya (16%), kamkonlik xomiladorni fiziologik faolligining buzillishi xomilada surunkali gipoksiya conducting of rh-sensitization tashxislash at patients with rh(-)blood blood analysis for the presence of antibodies and determining their titer: before 20 weeks of pregnancy it makes 1 time per month, after 20 weeks - ones every 2 weeks. indirect coombs' test, which allows you to determine which antibodies circulate in the blood, associated or free. rezus …

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delivery. in the presence of the fhd need early delivery as in the end of pregnancy increases the flow of rh antibodies to the fetus. the optimal timing of delivery - 37-38 weeks in severe edematous form of fhd interrupt pregnancy at any stage. rezus immunizatsiyali aellar tekshirish va tugruk turini tanlash maksadida statsionarga 34-36 xaftalikda etkizilishi shart gemolitik kasallik rivojlanishida darxol tugdirish kerak, chunki xomiladorlikni oxiriga borib at titri oshib boradi tugrukka optimal vakt 37-38 xafta shishli shaklining rivojlanishida gestatsiya muddatidan kat'iy nazar tugruk amalga oshiriladi management of labor tugrukni olib borish typically, delivery is performed vaginally. caesarean section is performed in the presence of additional obstetric complications. at readiness of the cervix produce amniotomy. if labors will not develop, within 5-6 hours after amniotomy begin labor induction with oxytocin or prostaglandins by the standard technique. odatda tabiiy tugruk kechadi. kesar kesish kushimcha akusherlik kursatmalari bulganda utkaziladi. etilgan bachadon …

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rh disease akusherlikda rezus omil lecturer: ayupova d.k. tashkent medical academy department of obstetrics №1 rh – iso-immunization definition pathophysiology management haemolitic disease fetus prevention ta'rifi patofiziologiya olib borish xomilani gemolitik kasalligi profilaktika rh factor proteins (antigens) occurring only on surface of rbc’s rh + if proteins present rh – if proteins absent a+, a-, b+, b-, ab+, ab-, o+, o- most important for pregnancy inheritance is autosomal dominant 15% caucasian population is rh- oksil (antigen)fakatgina eritrotsitlar yuzasidagina joylashadi rh + oksil mavjud rh – oksil yuk a+, a-, b+, b-, ab+, ab-, o+, o- odaida xomiladorlik davrida muxim nasliylikning autosom dominant turi 15% xalk rh- rh disease rezus mojaro occurs during pregnancy when there is...

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