klinicheskaya farmakologiya gipolipidemicheskix preparatov

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klinicheskaya farmakologiya gipolipidemicheskix preparatov giperlipidemiya – odna iz osnovnix prichin razvitiya as, a sledovatelno i ibs… 70% pojilix lyudey stradayut 15 millionov umirayut ejegodno pervichnie vtorichnie giperlipidemii 3 vtorichnie giperlipidemii x tg lvp zabolevanie pecheni perv.biliar. tsir. ++ n + obstr.jelch.put. ++ n  drugie alkogol n ++ + tiazidi n +  betablokatori n +  4 vtorichnie giperipidemii zabolevanie x tg lvp metabolicheskie/endokrinnie rasstr. gipotireoz ++ n n sd (type ii) + ++  sindrom kushinga + ++  zabolevaniya pochek xpn + +  nefrot. s-m ++ ++  5 opredelenie giperlipoproteinemiy po fridreksenu klassifikatsiya giperlipidemiy: tip giper- lipoproteinemii povisheno soderjanie aterogennost rasprostranennost i xm - 39 ia ox  x lvp 4.5-5.0 x lvp 24 1.opredelyaem xolesterin (u vsex >20 let ) norma – 1fr, to – dieta i ejegodniy kontrol ibs prisutstvuet ili 2fr, to – opredelyaem lpnp 2. profil lipoproteinov: tg, norma - ne …

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ey, koronarnoy smertnosti;  riska nefataln.im;  riska neobxodimosti operatsiy po revaskulyarizatsii miokarda; zamedlenie progressir. koronarnogo ateroskleroza. vklyuchaya snijenie razvitiya novix povrejdeniy 37 effektivnie dozi statinov lovastatin (mevakor) – 20-80mg simvastatin (zokor) – 10-40 mg fluvastatin (leskol) – 20-80 mg pravastatin (lipostat) – 10-40 mg 38 % patsientov, dostigshie tselevogo urovnya lpnp pri prieme 10 i 20 mg preparata jones ph et al //am j cardiol 2003;92:152-160 10mg simvastatin atorvastatin rozuvastatin 51 69 82 20mg simvastatin atorvastatin rozuvastatin 63 75 89 statini (protivopokazaniya) povishennaya chuvstvitelnost zabolevaniya pecheni (aktivnaya stadiya, ili neustanovlennoe) beremennost, period laktatsii pobochnie effekti uvelichenie aktivnosti transaminaz – regulyarniy kontrol v krovi,  >3 r.verxney grani-tsi normi – otmena preparata porajenie mishts – uvelichenie kfk, mialgii, slabost,  to toshnota, diareya, sip, zud, alopetsiya, sudorogi, pankreatit, perif.neyropatiya, angionevrotich.otek, krapivnitsa, lyupoidniy sindrom, vaskulit, artrit sekvestranti (absorbenti) jelchnix kislot xolestiramin (kvestran, kvantalan) kolestipol (kolestid) 43 sekvestranti (absorbenti) jelchnix kislot prepyatstvuyut …

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klinicheskaya farmakologiya gipolipidemicheskix preparatov giperlipidemiya – odna iz osnovnix prichin razvitiya as, a sledovatelno i ibs… 70% pojilix lyudey stradayut 15 millionov umirayut ejegodno pervichnie vtorichnie giperlipidemii 3 vtorichnie giperlipidemii x tg lvp zabolevanie pecheni perv.biliar. tsir. ++ n + obstr.jelch.put. ++ n  drugie alkogol n ++ + tiazidi n +  betablokatori n +  4 vtorichnie giperipidemii zabolevanie x tg lvp metabolicheskie/endokrinnie rasstr. gipotireoz ++ n n sd (type ii) + ++  sindrom kushinga + ++  zabolevaniya pochek xpn + +  nefrot. s-m ++ ++  5 opredelenie giperlipoproteinemiy po fridreksenu klassifikatsiya giperlipidemiy: tip giper- lipoproteinemii povisheno soderjanie aterogennost rasprostranennost i xm - 39 ia ox  x lvp 4.5-5.0 x lvp 24 1.op...

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