klinicheskaya farmakologiya preparatov,primenyayushixsya pri sindrome bronxialnoy obstruktsii

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slayd 1 klinicheskaya farmakologiya preparatov, primenyayushixsya pri sindrome bronxialnoy obstruktsii clinical pharmacology of drugs influencing the conductance of bronchi groups of bronchodilating drugs: adrenoreceptor stimulators: m-cholinoblockers: inhibitors of phosphodiesterase (methylxanthine) anti-inflammatory antiasthmatic preparations: glucocorticoids mast cell membrane stabilizing drugs blockers of leukotriene receptors expectorants, mucolytic and antitussives groups of medicine influencing the bronchial conductance α- and β-adrenostimulators epinephrin (adrenaline), efedrin, β1- and β2-adrenostimulators (non-selective) isoprenaline, orciprenaline; β2- adrenostimulators (selective): short-term effecting: salbutamole, fenoterole, terbutaline long-term effecting: formoterole, salmeterole adrenoreceptor stimulators: adenylatcyclase activation, relaxation of bronchial muscles; improving the discharging into the brochial lumen; lowers the bronchospastic effect of allergic mediators; reduces the excretion of chemotaxis factors and histamine from neutrophils and mast cells, appropriately; enhances the contraction ability of diaphragmal muscles; impacts on other organs except for lungs: increases the demand of myocardium to oxygen; improving the av conductance; enhancing the excitibility of myocardium; widening the coronary arteries; chrono and …

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nkrazia) relative contraindications: - high arterial pressure -angina pectoris - tireotoxicosis - tachiarythmias side effects when you exceed the dose or long taxifilaksiya resistance. v-block or metabolites through a reduction in the number of beta receptors is associated with resistance - a ricochet syndromeb2 receptor for a long time when stimulated mucosal edema and bronxiolalarning mucosa underground veins b1 receptor stimulation "obstruction syndrome"other: tachycardia, tremor, arrhythmia, hilpillovchi epithelial destruction, nausea, and a decrease in the oxygen potential pressure pde‘ 4 s non-selective inhibitors : short-acting – theophylline (of euphyllin, diafillin) long acting – teotart teopek retafil theo-24, unifil, eufilong pde‘4 s selective inhibitors: first generation: rolipram second generation: tsilomilast, piklamilast, roflumilast inhibitors of phosphodiesterase pervoe pokolenie ingibitorov fde4 (naprimer rolipram) bilo effektivnim v ingibirovanii aktivnosti vospalitelnix kletok, no ispolzovanie dannix preparatov bilo ogranicheno pobochnimi effektami, v chastnosti, so storoni jeludochno-kishechnogo trakta (barnette i underwood, 2000). ostavalas potrebnost v molekule s …

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ood circulation of coronary arteries. reduces peripheral vascular resistance. decreases blood pressure in pulmonary circulation. increases the contractility of diaphragma. pharmacokinetics of pdei poorly soluble in water, ethanol, so of euphyllin, aminofillin diafillin ditprofillin such drugs are used. 80-85% of their theophylline and 15% additives. eufilin after intravenous injection of the deposit amount will be decreased by the end of the first hour and 7 h after the general anikdanmaydi.metabolised in the liver, metabolic rate and the level of each patient is an original fsatkichlarga.ksantinlar metabolism speeds from 1 to 10 years, as well as some of the dv (gk, barbiturates, rifampicin) is received, the influence of smoking and increasing the amount of proteins in food, even if this process is accelerated. indications bronchial asthma chronic obstructive bronchitis, codl pulmonary hypertension pathology of breath (cheyn stock syndrome) pathology of brain blood circlation migrane * contraindications strong arterial hypotension, collapse, shock …

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nsion, asthma, bronxoreya dosage: 3-4 times a day to 2 breathe side effects: dry mouth, constipation, cough, local irritation, tachycardia, diplopia, allergic reactions contraindications: glaucoma, prostate adenoma m-cholinoblockers atropine and its quaternary derivatives: ipratropiy bromide (atrovent), tioropiy bromide, troventol. bronchodilating effect of ipratromiy bromide is 10 times greater than that of atropin less side effects to cns, salivary glands, heart rate, bp bronchodilating drugs efficiency and safety control methods the patient's clinical status assessment: breathing compressed to prevent attacks, breathing difficulties, cough, sputum discharge, reduction in physical indices. dosage order to determine the amount of theophylline blood. external respiratory activity before and after treatment. bronx expand drug selection for the b- adrenostimulator pharmacological test. the most common method is the b-adreno battery before and after a single inhalation of breath forced the size of the volume of the issue is 1 second. pikfloumetriya. a simple and reliable method is independent …

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ves mucociliary transport less systemic effect inhaled glucocorticoids for the treatment of bronchial asthma in adults inhaled glucocorticoids equal doses drugs an average daily dose, mkg small doses an average dose high dose beclomethasone dipropionate 200 - 500 500 - 1000 x 1000 budesonide 200 - 400 400 - 800 x 800 flunizolid 500 - 1000 1000 - 2000 x 2000 flyutikazon 100 - 250 250 - 500 x 500 triamtsinolon 400 - 1000 1000 - 2000 x 2000 side effetcs oral cavity and pharyngeal candidosis dysphonia bitter taste irritation of respiratory tract cough systemic effect in absorbtion the mast cell membrane stabilizators nedokromil sodium (tayled) kromoglitsinacid (cromoglycate sodium - intal) ketotifen (zaditen) – gistaminolytic effects the mast cell membrane stabilizators loss of phospholips activity of mast cells c-amp accumulation in mast cells membrane stabiling of mast cells free from leucocytes and inflammatory mediators only for prevention and treatment plan …

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slayd 1 klinicheskaya farmakologiya preparatov, primenyayushixsya pri sindrome bronxialnoy obstruktsii clinical pharmacology of drugs influencing the conductance of bronchi groups of bronchodilating drugs: adrenoreceptor stimulators: m-cholinoblockers: inhibitors of phosphodiesterase (methylxanthine) anti-inflammatory antiasthmatic preparations: glucocorticoids mast cell membrane stabilizing drugs blockers of leukotriene receptors expectorants, mucolytic and antitussives groups of medicine influencing the bronchial conductance α- and β-adrenostimulators epinephrin (adrenaline), efedrin, β1- and β2-adrenostimulators (non-selective) isoprenaline, orciprenaline; β2- adrenostimulators (selective): short-term effecting: salbutamole, fenoterole, terbutaline long-term effecting: formoterole, salm...

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