"educational-methodical recommendation (case - study) on clinical pharmacology of diuretics"

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health care ministry of uzbekistan tashkent medical academy department of clinical pharmacology case-technology «clinical pharmacology of diuretics» educational-methodical recommendation (case - study) is designed for teachers and students of vi-year medical institutions tashkent – 2015 educational abstract the subject: "clinical pharmacology" topic: "clinical pharmacology diuretics" the purpose of this case study: to develop students' ability to think creatively in the appointment of diuretic drugs, develop the ability to think logically in different clinical situations, deepening and broadening knowledge of edema syndrome expected learning outcomes - based on the results of work with a case students acquire the following knowledge and skills: • basic mechanisms of edema syndrome • modern classification of diuretics • the pharmacodynamic effects and pharmacokinetic parameters of various diuretics • assessment of the situation and its analysis; • appointment dosing regimen diuretics, taking into account the patient's age, depleting the functions of organs and forms edema syndrome; …

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and with other drugs this case reflects the real situation in terms of primary care. sources of information of the case: 1. the basic literature: 2. vg kukes. clinical pharmacology. moscow, 2008. 3. yb belousov. clinical pharmacology and pharmacotherapy. m., 2003. 4. ym mamadov. clinics pharmacology. tashkent, 2006. 5. bertram kattsung. basic and clinical pharmacology. m., 2001. 6. suvorov gy, martynov ai edematous syndrome: clinical picture m .: geotar-media, 2009. 7. renal physiology - vander. a - textbook, 2000 8. bagriy ae, ev shchukin - diuretics in modern clinical practice in 2012 characteristics of the case according to the typological features. this case is classified as a desk, a scene. he voluminous, structured, a question contains a set of facts case can be used in the disciplines: clinical pharmacology, internal medicine i case "clinical pharmacology lipid-lowering drugs" introduction diuretics - are drugs that act directly on the kidney leads to …

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ide diuretics -tiazidovye. b. kaliisberegayuschie, the drug enhances the excretion of sodium and potassium excretion blocking: -konkurentnye and non-competitive antagonists aldosterone. 3.po speed of onset and duration of diuresis diuretics can be divided into: a strong diuretic causing fast and relatively short-term diuretic effect (beginning no more than an hour, the duration of 5-8 hours): -petlevye- ocmoticheskie b. drugs expectancy and speed of action (beginning in a few hours, the duration of up to 12-24 hours): - thiazide - thiazide (without hlortolidona) - carbonic anhydrase inhibitors - non-competitive aldosterone antagonists. b. preparations delayed and prodolitelnym diuretic effect. (after a few days of onset, duration 24 hours): - hlortolidon - spironolokton 4. the effect on the acid-base balance of the blood, diuretics can be divided into: a cause marked metabolic acidosis: -ammoniya chloride, atsetozolamid b. causes mild metabolic acidosis with prolonged treatment with high doses: - amiloride, triamterene, spirololokton. b. cause …

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$ntial reduction in the effect of treatment for a few days: - ammonium chloride, atsetozolamid 7. the effect on the level of uric acid can be separated diuretics: a. increases the level of uric acid in the blood: - thiazide and thiazide. - loop b. does not significantly affect: - other. 9. posilen clinical effect of diuretics are divided into: a. strong (the rate of urine over 3 ml \ min): - causes 15-25% excretion of sodium profiltrogonnogo - loop 2. callers mostly water diuresis: - osmotic b. central forces that cause urinary 5-10% of the filtered sodium: - thiazide and thiazide. b. weaknesses: cause the excretion of less than 5% sodium profiltrogonnogo: - atsetozolamid - potassium-sparing. osmotic diuretics: mannitol, sorbitol, carbamide (urea) pharmacodynamics: - increases the osmotic pressure of the plasma - increases renal blood flow and glomerular filtration - 30% sodium excretion, excretion of water 15% - virtually …$

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anhydrase inhibitors: acetazolamide, diamox, diamoks, fonurit - intracranial hypertension: 250 mg 2 times a day 3-4 courses for 3 days with 3-day intervals pharmacokinetics: - good absorption, tmax 1-3 hours - distribution- red blood cells, plasma, kidney - ekskretsiya- tubular secretion and passive reabsorption, 24 hours, about 90% is excreted unchanged drug the indications and dosing regimen: - glaucoma otkratougolnaya 1-4raza 250 mg per day, secondary 250 mg 6 times per day --epilepsiya: 8-30 mg / kg in the reception 1-4 --otechnye syndrome: 5 mg / kg or 250-375 mg / day in 2 divided doses for intermittent 1-3 days - prevention of altitude bolezni- 0.5-1 g / day (250 mg four times) for 24-48 hours before and 48 hours after recovery contraindications to: - severe respiratory failure - uremia - cirrhosis - diabetes - severe hypokalemia - adrenal insufficiency. thiazide and nonthiazide diuretics pharmacodynamics: - 5-10% sodium excretion - …

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health care ministry of uzbekistan tashkent medical academy department of clinical pharmacology case-technology «clinical pharmacology of diuretics» educational-methodical recommendation (case - study) is designed for teachers and students of vi-year medical institutions tashkent – 2015 educational abstract the subject: "clinical pharmacology" topic: "clinical pharmacology diuretics" the purpose of this case study: to develop students' ability to think creatively in the appointment of diuretic drugs, develop the ability to think logically in different clinical situations, deepening and broadening knowledge of edema syndrome expected learning outcomes - based on the results of work with a case students acquire the following knowledge and skills: • basic mechanisms of edema syndrome • modern...

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