modern principles of therapy of hypertension

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slayd 1 modern principles of therapy of hypertension the prevalence of hypertension among the world's population suffer from ah 450 to 900 million man over 3 million annually die from complications ag hypertension affects more than 30% of the adult population of the republic of uzbekistan. according prof.kurbanova for rd, 2007 - working age 15-44% - elderly 60,7-65,8 the goal of treatment of hypertensive patients: reduce and normalize hypertension. preventing the occurrence of target organ damage, facilitating their return development. prevention of late complications of hypertension (stroke, myocardial infarction, heart failure and renal failure). the increase in life expectancy. principles of drug treatment of hypertension initiation of treatment with minimal doses of the drug; transition to another drug class with little effect of treatment (after increasing the dose of the first), or poor tolerance; the use of long-acting drugs to achieve the effect of 24 hours after a single administration.the …

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antagonists (d or k) step 1 a + k or a + d step 2 a + k + d step 3 additional: supplement with diuretics or ace drugs step4 according to who recommendations allocated 5 bases-classes of antihypertensive drugs for long-term treatment of hypertension: angiotensin converting enzyme (ace); blockers at 1 angiotensin receptors; thiazide (and thiazide) diuretic; blockers slow calcium channels; blockers beta-blockers; alpha blockers agonists central imidazoline receptors ace inhibitors pharmacokinetic classification ace inhibitors [on: l.opie (1994), as amended] class i lipophilic drugs: captopril, alacepril, altiopril class ii lipophilic prodrugs subclass iia drugs with predominantly renal elimination (60%): benazepril, quinapril, perindopril, cilazapril, enalapril subclass iib preparations with two main ways of elimination: moexipril, ramipril, fosinopril subclass iic drugs with predominantly hepatic elimination (60%): spirapril, trandolapril class iii hydrophilic drugs: lisinopril, libenzapril, ceronapril pharmacodynamic effects and-ace antihypertensive; vazodilatating; anti-ischemic; renoprotective; cardioprotective; angioproteguoe antiatherogenic; natriuretic. indications for use and-ace hypertension …

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channels) prevents intracellular hypercalcemia and contraction of smooth muscle cells maximum vasoselectivity amlodipine comparative characteristics of the cardiovascular effects of calcium antagonists heart rate myocardial contractility av conduction periphery-cal vazodilyattsiya amlodipine    ++++ nifedipine    +++ verapamil     + diltiazem    + pharmacodynamic effects of amlodipine antihypertensive; antianginal; vazodilyatiruyuschy. antisclerotic; antithrombotic; diuretic; weak natriuretic. cardioprotective action. crown promotes advancement blood supply infarction, reduction needs infarction in oxygenthat accompanied decreasing peripheral resistance vessels and increase stability membranes sarcolemma. effects on the kidneys. crown accelerates glomerular filtering and reduces level creatinine in blood. typically occursa small increase excretion sodium, but at this activity renin plasma and level aldosterone do not change. when angina crown authentically reduces frequency angina number episodes ischemia infarction ( volume includingand painless). in addition to direct vasodilating effect positive action at chd can be connected with his abilitydiminishing proliferation …

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slayd 1 modern principles of therapy of hypertension the prevalence of hypertension among the world's population suffer from ah 450 to 900 million man over 3 million annually die from complications ag hypertension affects more than 30% of the adult population of the republic of uzbekistan. according prof.kurbanova for rd, 2007 - working age 15-44% - elderly 60,7-65,8 the goal of treatment of hypertensive patients: reduce and normalize hypertension. preventing the occurrence of target organ damage, facilitating their return development. prevention of late complications of hypertension (stroke, myocardial infarction, heart failure and renal failure). the increase in life expectancy. principles of drug treatment of hypertension initiation of treatment with minimal doses of the drug; transitio...

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