"clinical pharmacology of hypolipidemics"

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ministry of health of the republic of uzbekistan tashkent medical academy department of clinical pharmacology case - technology "clinical pharmacology of hypolipidemics" educational-methodical recommendation (case - step) is designed for teachers and students of vi-year medical institutions tashkent - 2015 educational abstract the subject: "clinical pharmacology" topic: "clinical pharmacology of lipid-lowering agents" the purpose of this case study: to develop students' ability to think creatively in the appointment of lipid-lowering drugs, develop the ability to think logically in different clinical situations, deepening and broadening of knowledge on the syndrome of hyperlipidemia expected learning outcomes - based on the results of work with a case students acquire the following knowledge and skills: · basic mechanisms of hyperlipidemia and · modern classification hypolipidemia cal funds · pharmacodynamic effects and pharmacokinetic parameters of various lipid-lowering drugs · assessment of the situation and its analysis; · appointment dosing regimen of lipid-lowering agents, taking into …

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gents, taking into account peculiarities of the clinical situation, comorbidities, and other factors · methods for monitoring the effectiveness and safety of their hypolipidemia sanchez pm · indications and contraindications in the appointment of lipid-lowering drugs · side effects, prevention and correction mode · rational combination with other drugs this case reflects the real situation in terms of primary care. sources of information of the case: main references: 1. v.g kukes. clinical pharmacology. moscow, 2010. 2. y.b belousov. clinical pharmacology and pharmacotherapy. m., 2003. 3. y.m mamadov. clinics pharmacology. tashkent, 2003. 4. mamadov y.m. clinical pharmacology. t., 2010. 697 b. 5. p.s katz, i.r mavlyanov, r.k mahkamova clinical pharmacology t 2012 6. training program on employment. further reading 1. bertram kattsung. base and clinical pharmacology. m. 2001. 2. toolkit "clinical - pharmacological approach to choice medicinal money to treatment coronary failure. " 3. toolkit "giperlipidemiyani davolashda qo'llaniladigan dori vositalarini tayinlash …

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648. 12. heart protection study colloborative group. mrc / bhf heart protection study of cho-lesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial // lancet.- 2002.- vol.360.- p.7-22. 13. statins and heart failure "farmindeks -praktik" number 7 year 2005 14. journal articles and 15. information from the internet: www.tma.uz , www.ziyonet.uz , www.book.ru , www.n urse .com , medinfa.ru . characteristics of the case according to the typological characteristics. this case is classified as a desk, a scene. he voluminous, structured, a question, contains a collection of facts. according to the didactic goals case training, stimulating thinking in the real situation in terms of sap and gwp. case can be used in the disciplines: clinical pharmacology, internal medicine i case "clinical pharmacology lipid-lowering drugs" introduction since then, as a result of long-term population studies in a number of countries have been able to confirm the link between …

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triglycerides, phospholipids are transported in a complex with proteins. in addition fatty acids that bind preferentially albumin, all the lipids are transported in special macromolecular complexes lipoproteins. therefore, metabolic disorders, which increases the content of lipoproteins of plasma called hyperlipidemia. hyperlipemia term is used in cases where increased plasma triglycerides. the concept of hyperlipidemia includes both groups of states. the two main consequences of hyperlipidemia - is acute pancreatitis and atherosclerosis. acute pancreatitis occurs in severe hyperlipidemia. a key role in atherogenesis operate macrophages and smooth muscle cells. to capture via specific lipoprotein receptors on these cells (receptor-cleaners) their oxidation leads that generates foam cells in which cholesterol esters are cumulated. among the lipoproteins are distinguished: chylomicrons, very low density lipoproteins (lpon) low density lipoproteins (ldl), intermediate density lipoprotein (idl) lipoprotein (a) - (lp (a)). these lipoproteins are atherogenic. and also distinguish -lipoproteidy high density lipoproteins (hdl), which are antiatherogenic. …

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as several isoforms. isoform of this protein should be recognized by the receptors of the liver, to capture its residual lipoproteins. apo-e is responsible for the recognition of a specific receptor and the capture of lipoproteins. chylomicra - largest of lipoproteins are basic transport exogenous fat form and formed in the intestine and contain triglycerides (85%) of foodborne; stabilize the shell chylomicron proteins, phospholipids contain apo b-48, apo a-1, a-ii apo and apo s. chylomicra pass into the extracellular space and lymphatic intestinal lymphatics and thoracic duct are transferred into the bloodstream. after entering the bloodstream (half-life is several minutes) until they break remnantnyh particles by the enzymatic activity of lipoprotein lipase situated in muscle and adipose tissue. triglycerides are derived from the chylomicrons in the tissues (except liver) hydrolysis lipoproteinlipaznoy system (lpl). by reducing the amount of triglycerides central particle size decreases. surface lipids - apo a-1, apo-ii, apo-transfer …

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ministry of health of the republic of uzbekistan tashkent medical academy department of clinical pharmacology case - technology "clinical pharmacology of hypolipidemics" educational-methodical recommendation (case - step) is designed for teachers and students of vi-year medical institutions tashkent - 2015 educational abstract the subject: "clinical pharmacology" topic: "clinical pharmacology of lipid-lowering agents" the purpose of this case study: to develop students' ability to think creatively in the appointment of lipid-lowering drugs, develop the ability to think logically in different clinical situations, deepening and broadening of knowledge on the syndrome of hyperlipidemia expected learning outcomes - based on the results of work with a case students acquire the following knowled...

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