diphtheria and diphtheria toxoid

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powerpoint presentation diphtheria and diphtheria toxoid epidemiology and prevention of vaccine-preventable diseases national immunization program centers for disease control and prevention revised march 2002 1 diphtheria greek diphtheria (leather hide) recognized by hippocrates in 5th century b.c. epidemics described in 6th century c. diphtheriae described by klebs in 1883 toxoid developed in 1920s 2 corynebacterium diphtheriae aerobic gram-positive bacillus toxin production occurs only when c. diphtheriae infected by virus (phage) carrying tox gene if isolated, must be distinguished from normal diphtheroid 3 diphtheria clinical features incubation period 2-5 days (range, 1-10 days) may involve any mucous membrane classified based on site of infection anterior nasal tonsillar and pharyngeal laryngeal cutaneous ocular genital 4 pharyngeal and tonsillar diphtheria insidious onset of exudative pharyngitis exudate spreads over 2-3 days and may form adherent membrane membrane may cause respiratory obstruction fever usually not high but patient appears toxic 5 diphtheria complications most attributable …

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nted for many cases 12 dtap, dt, and td dtap, dt td (adult) diphtheria 7-8 lf units 2 lf units tetanus 5-12.5 lf units 5 lf units pertussis vaccine and pediatric dt used through age 6 years. adult td used for persons 7 years and older. 13 diphtheria toxoid formalin-inactivated diphtheria toxin schedule three or four doses + booster booster every 10 years efficacy approximately 95% duration approximately 10 years should be administered with tetanus toxoid as dtap, dt, or td 14 routine dtap primary vaccination schedule dose primary 1 primary 2 primary 3 primary 4 age 2 months 4 months 6 months 15-18 months interval --- 4 wks 4 wks 6 mos 15 children who receive dt the number of doses of dt needed to complete the series depends on the child’s age at the first dose: if first dose given at 12 months, 3 doses complete the primary …

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powerpoint presentation diphtheria and diphtheria toxoid epidemiology and prevention of vaccine-preventable diseases national immunization program centers for disease control and prevention revised march 2002 1 diphtheria greek diphtheria (leather hide) recognized by hippocrates in 5th century b.c. epidemics described in 6th century c. diphtheriae described by klebs in 1883 toxoid developed in 1920s 2 corynebacterium diphtheriae aerobic gram-positive bacillus toxin production occurs only when c. diphtheriae infected by virus (phage) carrying tox gene if isolated, must be distinguished from normal diphtheroid 3 diphtheria clinical features incubation period 2-5 days (range, 1-10 days) may involve any mucous membrane classified based on site of infection anterior nasal tonsillar and pharynge...

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