fiziologiya mikrotsirkulyatsii

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slayd 1 fiziologiya mikrotsirkulyatsii. osobennosti krovoobrasheniya * mikrotsirkulyatsiya – eto dvijenie krovi i limfi po sosudam, diametr kotorix menee 200mkm, a takje transport razlichnix veshestv cherez stenki sosudov i mejkletochnie promejutki * * sxema mikrotsirkulyatornogo sosudistogo rusla * mikrotsirkulyatornaya edinitsa limfaticheskiy kapillyar * tipi kapillyarov magistralnie kapillyari bokovie kapillyari i kapillyarnie seti dejurnie kapillyari (25%) plazmaticheskie kapillyari (10%) molchashie kapillyari (65%) somaticheskie vistseralnie ili fenestrirovannie sinusoidalnie so shelyami * obshie svoystva kapillyarov obshee kolichestvo - 40 milliardov diametr - 5-8 mkm, dlina 0,5 - 1,1 mm summarnaya dlina vsex kapillyarov – 100 000 km naimenshaya lineynaya skorost krovi - 50 sm2/g ochen maloe rasstoyanie mejdu krovyu i kletkami tkani - v endokarde v sistolu > v epikarde * * faktori, opredelyayushie velichinu perfuzionnogo davleniya (pd) v koronarnoy sisteme * mozgovoy krovotok * na golovnoy mozg prixoditsya 20% serdechnogo vibrosa v srednem mozgovoy krovotok sostavlyaet 50 – 60 ml/100 g/min. kriticheskoe …

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gumoralnaya regulyatsiya fizicheskiy - regulyatsiya v zavisimosti ot urovnya vnutricherepnogo davleniya miogenniy - regulyatsiya v zavisimosti ot stepeni rastyajeniya sosudov * faktori, opredelyayushie davlenie krovi v mozgovix sosudax vnutri-mozgovoe davlenie mestnaya konstriktsiya ili dilatatsiya mozgovix arteriy srednee arterialnoe davlenie ob'em krovotoka srednee venoznoe davlenie * no i ego istochniki v golovnom mozge no sinteziruetsya no-sintazoy iz l-arginina v kletkax endoteliya sushestvuyut neyroni, sposobnie sintezirovat no obnarujeni kletki glii, sinteziruyushie no v polushariyax golovnogo mozga no-sintaza obnarujena v 1% neyronov, lokalizovannix v oblastyax, svyazannix s obonyaniem i zreniem v serom veshestve opisani dva spleteniya nervnix volokon, soderjashix no-sintazu - poverxnostnoe i glubokoe. v telax i okonchaniyax kletok etix spleteniy nakaplivaetsya no. * deyatelnost sistemi regulyatsii mozgovogo krovoobrasheniya: funktsionalnaya ili rabochaya giperemiya; zavisimost krovotoka ot soderjaniya gazov v krovi autoregulyatsiya mozgovogo krovotoka; autoregulyatsiya – fenomen nezavisimosti urovnya krovotoka cherez golovnoy mozg ot izmeneniy krovyanogo davleniya v predelax ot 60 do 180mm rt …

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isteme legochnogo krovoobrasheniya pravoe predserdie =0 mmhg praviy jeludochek: sistolich.=25 mmhg, diastolich.=0 mmhg legochnaya arteriya: srednee=15 mmhg, sistolich.=25 mmhg, diastolich.=8 mmhg kapillyarnoe gidrostaticheskoe davlenie ~8–10 mmhg levoe predserdie ~5 mmhg  davlenie v malom kruge namnogo nije, chem v bolshom * prichini nizkogo davleniya legochnie sosudi koroche i imeyut bolee tonkuyu stenku s menshim mishechnim sloem bolshaya rastyajimost legochnix arteriy (sm. ris.) malaya velichina sosudistogo soprotivleniya (30% soprotivleniya – arterii, 50% - arterioli i venuli, 20% - veni) * sledstviya nizkogo davleniya absolyutnie velichini davleniy v legochnoy arterii namnogo nije, chem v aorte  pri maloy rabote pravogo jeludochka obespechivaetsya prodvijenie vsey krovi po malomu krugu. pulsovoe davlenie otnositelno bolshe, chem v aorte  v period sistoli iz-za malogo soprotivleniya bolshaya chast sistolicheskogo ob'ema krovi perexodit v legochnie veni. * gipoksicheskaya vazokonstriktsiya nablyudaetsya i na izolirovannix legkix vozmojniy mexanizm: kislorod blokiruyutsya k-kanali depolyarizatsiya vxod sa++ sokrashenie gladkix mishts sosudov * …

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terioli kapillyari pochechnix klubochkov vinosyashie arterioli peritubulyarnie kapillyari venuli pryamie sosudi home_inside: rov postupaet v pochku po pochechnoy arterii , kotoraya razvetvlyaetsya snachala na mejdolevie arterii , zatem na dugovie arterii i mejdolkovie arterii , ot poslednix otxodyat prinosyashie arterioli , snabjayushie krovyu klubochki. iz klubochkov krov, ob'em kotoroy umenshilsya, ottekaet po vinosyashim arteriolam. dalee ona techet po seti peritubulyarnix kapillyarov , naxodyashixsya v pochechnom korkovom veshestve i okrujayushix proksimalnie i distalnie izvitie kanaltsi vsex nefronov i petli genle korkovix nefronov. ot etix kapillyarov otxodyat pochechnie pryamie sosudi , idushie v pochechnom mozgovom veshestve parallelno petlyam genle i sobiratelnim trubkam. funktsiya obeix sosudistix sistem - vozvrashenie krovi, soderjashey tsennie dlya organizma pitatelnie veshestva, v obshuyu krovenosnuyu sistemu. cherez pryamie sosudi protekaet znachitelno menshe krovi, chem cherez peritubulyarnie kapillyari, blagodarya chemu v interstitsialnom prostranstve pochechnogo mozgovogo veshestva podderjivaetsya visokoe osmoticheskoe davlenie, neobxodimoe dlya obrazovaniya kontsentrirovannoy mochi. 20 mm rt. st 60 …

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dtsu 1. vis a fronte (sila speredi): a) otritsatelnoe davlenie v grudnoy polosti (prisasivayushaya rol dixaniya) b) otritsatelnoe davlenie v uste predserdiy v diastolu (prisasivayushaya rol serdtsa) 2. vis a tergo (sila szadi): a) ostatochnaya kineticheskaya energiya serdtsa v vide davleniya krovi v kontse kapillyarov b) sokratitelnaya deyatelnost skeletnix mishts ( mishechniy «nasos» krovi) izmeneniya koronarnogo krovotoka vo vremya sistoli i diastoli v raznix sloyax miokarda levogo jeludochka (lj) i ii i narujniy lj sredniy vnutrenniy i ii i i - sistola ii - diastola puc. 695. crpoenne crenku aprepun (a), nenut (b) m amiarnaecxoro cocyaa b (cxesta). - bce m0 iza nen ina ene meguunue. ‘goo, tunica media; pe eee com a eg venosa; $—amuparicicit kaman, valvala iympatics. q anne “a 'ephono-beh/nadhbii ss npeakanunnapriie cab umtepes mpeqnoururensaesit kanunnapaste cibunitepel bexyna kanunnspet kanuanappr aptepho-beho3hbiit ahactomo3 bi dxexrponmter tluratenpupre beutectra © tpoayets: mera6onn3ma simm atiueckuit cocya nee mexanerounas, cs=30+99 benyna ounerpayna …

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slayd 1 fiziologiya mikrotsirkulyatsii. osobennosti krovoobrasheniya * mikrotsirkulyatsiya – eto dvijenie krovi i limfi po sosudam, diametr kotorix menee 200mkm, a takje transport razlichnix veshestv cherez stenki sosudov i mejkletochnie promejutki * * sxema mikrotsirkulyatornogo sosudistogo rusla * mikrotsirkulyatornaya edinitsa limfaticheskiy kapillyar * tipi kapillyarov magistralnie kapillyari bokovie kapillyari i kapillyarnie seti dejurnie kapillyari (25%) plazmaticheskie kapillyari (10%) molchashie kapillyari (65%) somaticheskie vistseralnie ili fenestrirovannie sinusoidalnie so shelyami * obshie svoystva kapillyarov obshee kolichestvo - 40 milliardov diametr - 5-8 mkm, dlina 0,5 - 1,1 mm summarnaya dlina vsex kapillyarov – 100 000 km naimenshaya lineynaya skorost krovi - 50 sm2/g och...

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