surunkali gepatitlar

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kliniko-immunologicheskie osobennosti hbv-infektsii u detey, infitsirovannix razlichnimi genotipami virusa bolalarda surunkali gepatitlar: ta'rifi surunkali gepatit (sg) – 6 oydan ziyod jigar to'qimasining diffuz yallig'lanishiga aytiladi. jigar funktsiyalari: belkovosinteticheskaya jelcheobrazuyushaya dezintoksikatsionnaya (ili obezvrejivayushaya) energoobrazuyushaya i energosoxranyayushaya depo jeleza i vitaminov uchastie v protsessax gemostaza chto takoe mejdolkovaya pechenochnaya triada? stroenie pechenochnoy dolki (v ob'eme) imholtz a., phd. prince george's community college. * * hujayraning membranali tuzilmalari hujayradagi barcha almashinuv jarayonlari membranali tizimlar bilan bog'liq bo'lib, ularning faoliyati fosfolipid tuzilmalar butunligiga bog'liqdir. hujayra membranasi golji kompleksi endoplazmatik to'r mitoxondriya yadro * kak vi vidite na etom slayde – kletka i ee membrannie strukturi – obolochka samoy kletki (ee funktsii – zashitnaya, transportnaya, obespechenie gomeostaza, delenie, rabota belkov i retseptorov, raspolojennix na ney i mnogie drugie; mitoxodrii – obespechenie kletki energiey; kompleks goldji – sekretornaya funktsiya, a takje obezvrejivanie toksichnix produktov; endoplazmaticheskiy retikulum – sintez belka, yadro – xranenie geneticheskoy informatsii, delenie i …

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rdagi ma'lumotlarga ko'ra 40% ortiq katta yoshdagi bemorlar bolaligida svgv bilan kasallanganlar. 16–21 yildan keyingi yaponiyadagi t. fujisawa et al. (2000 g.) kuzatuvlariga asoslanib svgv bilan kasallangan bolalarning 3,8%ida gepatokartsinoma aniqlangan. hozirgi vaqtda aniqlangan virusli gepatitlar orasida surunkali gepatit etiologiyasida v (hbv), s (hcv) i delta (hdv) viruslari aniqlangan. surunkali jarayonga aylantiruvchi virusologik omillar. gepatit virusi (eng ko'p chastotada hcv) gepatit virusi genotipi virus o'zgaruvchanligi darajasi virus miqdori (qondagi viruslar miqdori) gepatit vning okibati o'tkir vgv to'liq tuzalish 75-85% surunkali gepatit v 15-25% “simptomsiz yoki faol jigar tsirrozi 5% h c kartsinoma 1-2 %/god yil0 30 yil fibrozning ortishi * hcv infektsiya: "fakti" otsenennaya vsemirnaya rasprostranennost hcv infektsii - 170 millionov, priblizitelno 3 % vsemirnogo naseleniya. priblizitelno 3 - 4 milliona individuumov nedavno zarajeni(infitsirovani) hcv kajdiy god 1 nekotorie sluchai(dela) ostroy bolezni samoogranichivayut, i v techenie nedel posle nachala priznaka, hcv rkn stanovitsya neobnarujimim, i urovni aminotransferase normalizuyut. k sojaleniyu, …

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jegodno 3 hcv infektsiya - glavniy faktor riska dlya razvitiya sereznoy bolezni pecheni stadii(stseni) kontsa, vklyuchaya hepatocellular kartsinoma (hcc). v techenie 20 let posle nachala hcv infektsii, 1 % 5 % patsientov s hcv (s ili bez tsirroza pecheni) razvivaet hcc.4, xotya polnostyu ne ponimaetsya, kak hcv prodvijeniya(progress) infektsii k raku pecheni, bolshinstvo sluchaev(del) proisxodit v cirrhotic patsientax, predlagaya, chto eto yavlyaetsya osnovnoy boleznyu pecheni, kotoraya yavlyaetsya faktorom riska dlya hcc.4,5 sredi tex s hcv i ustanovlennim tsirrozom pecheni, ejegodnaya sfera deystviya hcv - 1 % k 4 %-an, uvelichil risk po sravneniyu s temi bez ustanovlennogo tsirroza pecheni 2 mujskoy rod, starshiy vozrast v nachale hcv infektsii, i potrebleniya alkogolya izlagaet uvelichenniy risk hcc v cirrhotic patsiente 2,4 1. kto. gepatit c. fakticheskie dannie nomer 164. 2. tsentr kontrolya zabolevaniy. mmwr. 1998; 47 (reaktsiya na obluchenie 19):1-39. 3. tsentr kontrolya zabolevaniy. gepatit c dvigaet komplekt. 25 sentyabrya 2000. 4. …

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i progressiya hcv infektsii k sushestvennomu povrejdeniyu(usherbu) pecheni mojet vzyat 20 let ili bolshe. v techenie pervix desyatiletiy posle infektsii, bolezn svyazana bez priznakov ili fizicheskix priznakov(podpisey) i, sledovatelno, otnositelno nizkaya chastota smertnosti. v techenie 20 - 30 let, 10 % 20 % xronicheski zarajennix(infitsirovannix) patsientov razvivayut patsientov tsirroza pecheni 2, kotorie razvivayutsya, tsirroz pecheni v techenie etogo perioda, bolee veroyatno, umret ot svyazannix s pechenyu prichin chem ot hcv infektsii. smertnost ot xronicheskoy bolezni pecheni raspolagaetsya ot 1 % do 5 % ejegodno 3 hcv infektsiya - glavniy faktor riska dlya razvitiya sereznoy bolezni pecheni stadii(stseni) kontsa, vklyuchaya hepatocellular kartsinoma (hcc). v techenie 20 let posle nachala hcv infektsii, 1 % 5 % patsientov s hcv (s ili bez tsirroza pecheni) razvivaet hcc.4, xotya polnostyu ne ponimaetsya, kak hcv prodvijeniya(progress) infektsii k raku pecheni, bolshinstvo sluchaev(del) proisxodit v cirrhotic patsientax, predlagaya, chto eto yavlyaetsya osnovnoy boleznyu pecheni, kotoraya yavlyaetsya …

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splantatsiya yoki o'lim immun javob to'qima shikastlanishi fibroz gtsk tsirroz kasallik ko'rinishi surunkali virusli gepatitlar patogenezi. adapted from dr z goodman, armed forces institute of pathology, washington, dc xujayin omillari va tashqi muhit (alkogol, koinfektsiya va boshka.) * jigardagi asosiy kasalliklar sindromi tsitoliz sindromi jigar ichi va jigardan tashqari xolestaz sindromi gepatotsitlar toksik shikastlanishi sindromi gepatotsitlarda sintez jarayoni buzilishi sindromi yallig'lanish sindromi tsitoliz sindromi tsitoliz infektsion gepatitga, jigarning toksik shikastlanishi,zaharlanishlarga xarakterli. tsitoliz gepatotsitlar membranasi va organellalari butunligini buzilishiga asoslangan bo'lib, giperfermentemiya bilan kechadi. tsitoliz zardobda alt, ast, ldg, gldg ortishi bilan kechadi. - membrananing o'tkazuvchanligini ortishini plazmada quyidagilarni ortishi bilan baholanadi: tsitoplazmatik fermentlar - alt. ast. ldg mitoxondrial fermentlar- gldg, ast tsitoliz sindromini ldg-5 tasdiqlaydi 1 2 3 4 5 ldg o't chiqaruvchi yo'llar epiteliysining reaktiv o'zgarishlari, jigar ichi xolestaz ko'rinishlarini if, -gt, lap faolligi aks ettiradi. o't chiqaruvchi yo'llar membranasida fermentlar birga joylashgan, ularning faolligi bir vaqtda bir xil …

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kliniko-immunologicheskie osobennosti hbv-infektsii u detey, infitsirovannix razlichnimi genotipami virusa bolalarda surunkali gepatitlar: ta'rifi surunkali gepatit (sg) – 6 oydan ziyod jigar to'qimasining diffuz yallig'lanishiga aytiladi. jigar funktsiyalari: belkovosinteticheskaya jelcheobrazuyushaya dezintoksikatsionnaya (ili obezvrejivayushaya) energoobrazuyushaya i energosoxranyayushaya depo jeleza i vitaminov uchastie v protsessax gemostaza chto takoe mejdolkovaya pechenochnaya triada? stroenie pechenochnoy dolki (v ob'eme) imholtz a., phd. prince george's community college. * * hujayraning membranali tuzilmalari hujayradagi barcha almashinuv jarayonlari membranali tizimlar bilan bog'liq bo'lib, ularning faoliyati fosfolipid tuzilmalar butunligiga bog'liqdir. hujayra membranasi golji...

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