rezus-faktor v akusherstve. immunokonfliktnaya beremennost: po rezus-antigenu i sistemami avo. gemoliticheskaya bolezn ploda

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rh disease rezus-faktor v akusherstve. immunokonfliktnaya beremennost: po rezus-antigenu i sistemami avo. gemoliticheskaya bolezn ploda. lecturer: assisant professor, f.i.shukurov tashkent medical academy department of obstetrics and gynecology №1 rh – iso-immunization definition pathophysiology management haemolitic disease fetus prevention opredelenie patofiziologiya taktika vedeniya gbp i gbn profilaktika rh factor proteins (antigens) occurring only on surface of rbc’s rh + if proteins present rh – if proteins absent a+, a-, b+, b-, ab+, ab-, o+, o- most important for pregnancy inheritance is autosomal dominant 15% caucasian population is rh- belok (antigen) vstrechayushiysya tolko na poverxnosti eritrotsitov. rh + pri nalichii belka rh – pri otsutstvii a+, a-, b+, b-, ab+, ab-, o+, o- naibolee vajen vo vremya beremennosti autosomno-dominantniy tip nasledovaniya 15% naseleniya rh- rh disease rezus konflikt occurs during pregnancy when there is an incompatibility between the blood types of the mother and fetus vstrechaetsya vo vremya beremennosti, pri nesovmestimosti mejdu …

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d antitela naibolee chasto vstrechayutsya u beremennix chem anti-k, anti-c i anti-e. nesovmestimost po abo redko vizivaet gemoliz monitoring for rbc isoimmunisation obsledovat beremennuyu na gruppu krovi i anti-k, anti-c i anti-e antitela k eritrotsitam povtornoe obsledovanie v 3 trimestre 98.5% rezus konfliktov predotvrashayutsya vvedeniem anti-d. 99.9% rezus konfliktov mogut bit predotvrasheni rutinnim vvedeniem anti-d v tretem trimestre. povtornoe obsledovanie v 28 nedel i zatem vvedeniem anti-d v 28 i 34 nedeli blood group and rbc antibody anti-k, anti-c, and anti-e screen for all pregnant women retest at least once in the 3rd trimester 98.5% of rhesus d disease is prevented by event-stimulated administration of anti-d 99.9% of rhesus d disease can be prevented by routine administration anti-d in the 3rd trimester. test at 28 weeks and then give anti-d at 28 and 34 weeks rh- iso imunization rezus izoimmunizatsiya fetomaternal hemorrhage has been documented in: 7% in the first …

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sirkulyatsiyu v bolshinstve rodov menee chem v 0,1 ml krovi, no v obshem ne aktiviruyut aktivniy immunniy otvet rezus antigen vizivaet otvet klonov v limfotsitov raspoznayushix chujerodnie eritrotsitarnie antigeni pathophysiology patofiziologiya initial igm followed by igg in 2 wks- 6 mths memory b lymphocytes activate immune response in subsequent pregnancy igg ab cross placenta and attach to fetal rbc’s cells then sequestered by macrophages in fetal spleen where they get hemolyzed fetal anemia pervichniy igm perexodit v iggga ot2 nedel do 6 mesyatsev pamyat v limfotsitov aktiviruet immunniy otvet pri posleduyushey beremennosti igg at proxodyat cherez platsentu i atakuyut fetalnie eritrotsiti kletki pererabativayutsya makrofagami v selezenke ploda gde oni gemolizirovalis u ploda razvivaetsya anemiya rh antibodies rh - antitela there are 3 types of rh antibodies: agglutinating, blocking, hidden. sushestvuet tri vida rh - antitel agglyutiniruyushie, blokirovannie, skritie. agglutinating antibody give a visible agglutination with rh positive red blood cells …

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kritimi nazivayut takie antitela, kotorie viyavlyayutsya tolko v razvedenii sivorotkoy av. blokiruyushie antitela, ne davaya vidimoy reaktsii agglyutinatsii, blokiruyut eritrotsiti. obladaya bolee nizkim molekulyarnim vesom, chem agglyutiniruyushie antitela, oni legko proxodyat cherez platsentu i imeyut bolshoe znachenie v patogeneze gbn. hemolytic disease of the fetus (hdf) a disorder of the fetus in which fetal red blood cells are destroyed by maternal igg antibodies the igg antibodies cross the placenta and shorten red cell survival the premature red cell destruction results in disease varying from mild anemia to death in uterus narusheniya u ploda v rezultate razrusheniya eritrotsitov ploda antitelami materi antitela igg pronikayut cherez platsentu i sokrashayut vijivaemost eritrotsitov prejdevremennoe razrushenie eritrotsitov privodit k patologii ot anemii do smerti ploda etiology in fetus the mother is exposed during first pregnancy in a subsequent pregnancy, igg antibodies cross the placenta the antigens bind to fetal cells and red cells are destroyed, …

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tenzii (23%). course of pregnancy techenie beremennosti in the second half of pregnancy edema (13%), pre-eclampsia (16%), anemia observed. disturbances of mother’s live function chronic fetal hypoxia oteki vo vtoroy polovine beremennosti (13%), preeklampsiya (16%), anemiya narushenie fiziologicheskoy aktivnosti materi xronicheskaya gipoksiya u ploda conducting of rh-sensitization pregnancy at patients with rh(-)blood blood analysis for the presence of antibodies and determining their titer: before 20 weeks of pregnancy it makes 1 time per month, after 20 weeks - ones every 2 weeks. indirect coombs' test, which allows you to determine which antibodies circulate in the blood, associated or free. patsientkam s rezus – krovyu analiz krovi na nalichie antirezusnix antitel i ix titr do 20 ned beremennosti 1 raz v mesyats, posle 20 ned beremennosti kajdie 2 nedeli nepryamaya reaktsiya kumbsa, pozvolyaet opredelit kakie antitela tsirkuliruyut v krovi, svobodnie ili svyazannie conducting of rh-sensitization pregnancy ultrasound is performed every week …

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rh disease rezus-faktor v akusherstve. immunokonfliktnaya beremennost: po rezus-antigenu i sistemami avo. gemoliticheskaya bolezn ploda. lecturer: assisant professor, f.i.shukurov tashkent medical academy department of obstetrics and gynecology №1 rh – iso-immunization definition pathophysiology management haemolitic disease fetus prevention opredelenie patofiziologiya taktika vedeniya gbp i gbn profilaktika rh factor proteins (antigens) occurring only on surface of rbc’s rh + if proteins present rh – if proteins absent a+, a-, b+, b-, ab+, ab-, o+, o- most important for pregnancy inheritance is autosomal dominant 15% caucasian population is rh- belok (antigen) vstrechayushiysya tolko na poverxnosti eritrotsitov. rh + pri nalichii belka rh – pri otsutstvii a+, a-, b+, b-, ab+, ab-, o+, o- ...

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