vozbuditeli gemorragicheskoy lixoradki

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powerpoint presentation vozbuditeli gemorragicheskoy lixoradki, shoxruz tulaganov 1. diagnostika, profilaktika i lechenie 2. mexanizmi patogeneza i peredachi 3. virusi gemorragicheskix lixoradok: obzor plan: patogenez i mexanizmi zabolevaniya virusnie chastitsi, pronikaya v kletki-misheni (endotelialnie kletki, makrofagi), indutsiruyut apoptoz i nekroz, vizivaya povrejdenie sosudistoy stenki i narushenie gemostaza, chto privodit k razvitiyu krovoizliyaniy razlichnoy stepeni virajennosti. v patogeneze klyuchevuyu rol igrayut narusheniya koagulyatsii, proyavlyayushiesya v vide dvs-sindroma v 30-70% sluchaev, obuslovlennie kak pryamim povrejdeniem endoteliya, tak i aktivatsiey kaskada svertivaniya krovi. replikatsiya virusa v kletkax vizivaet moshniy tsitokinoviy shtorm, xarakterizuyushiysya povisheniem urovnya tnf-α, ifn-γ i drugix provospalitelnix tsitokinov, usugublyaya povrejdenie tkaney i organnuyu disfunktsiyu. klinicheskie proyavleniya i simptomi porajenie pecheni, proyavlyayusheesya povisheniem urovnya pechyonochnix transaminaz (alt i ast) v 2-3 raza vishe normi, yavlyaetsya chastim priznakom mnogix tipov gemorragicheskix lixoradok. nachalnie simptomi, takie kak lixoradka (vishe 38,5°c), mialgiya i golovnaya bol, chasto nespetsifichni i mogut imitirovat gripp, zatrudnyaya rannyuyu diagnostiku gemorragicheskix lixoradok. …

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si ebola i marburg), otlichayas po strukture genoma i antigennim svoystvam. virusi xarakterizuyutsya razlichnoy stepenyu patogennosti, s letalnostyu, variruyushey ot menee 1% (naprimer, nekotorie bunyaviridae) do bolee 90% (naprimer, nekotorie shtammi virusa ebola), v zavisimosti ot vida virusa i shtamma. virusi gemorragicheskoy lixoradki: obzor bolee 19 vidov virusov vizivayut gemorragicheskuyu lixoradku, rasprostranyayas cherez razlichnie puti peredachi, vklyuchaya kontakt s infitsirovannimi jivotnimi, aerozolyami i peredachu cherez vektor (naprimer, kleshey). virusi gemorragicheskoy lixoradki, takie kak virus ebola i marburg, imeyut visokuyu smertnost, dostigayushuyu 90% v nekotorix vspishkax, i xarakterizuyutsya gemorragicheskim sindromom i mnogoorgannoy nedostatochnostyu. lechenie gemorragicheskix lixoradok chasto podderjivayushee, fokusiruyas na simptomaticheskoy terapii, gidratatsii i podderjke funktsiy jiznenno vajnix organov; spetsificheskie protivovirusnie preparati imeyutsya ne dlya vsex virusov. globalnoe rasprostranenie i epidemiologiya globalnoe rasprostranenie virusov gemorragicheskoy lixoradki oxvativaet bolee 100 stran, s naibolshey zabolevaemostyu v tropicheskix i subtropicheskix regionax afriki i yujnoy ameriki, gde usloviya blagopriyatstvuyut rasprostraneniyu perenoschikov. bolee 80% sluchaev zarajeniya …

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aktiki. strogiy kontrol za perenoschikami virusov, naprimer, grizunami (do 80% sluchaev zarajeniya), vklyuchaet dezinsektsiyu i deratizatsiyu v endemichnix rayonax. effektivnost vaktsinatsii protiv nekotorix gemorragicheskix lixoradok dostigaet 90%, snijaya risk zabolevaniya i smertnosti sredi vaktsinirovannix grupp naseleniya. diagnostika i lechenie diagnostika gemorragicheskix lixoradok chasto vklyuchaet analiz krovi na nalichie virusnoy rnk metodom ptsr, s chuvstvitelnostyu do 95% v ostroy faze zabolevaniya. spetsificheskaya protivovirusnaya terapiya dlya nekotorix gemorragicheskix lixoradok, naprimer, ebola, ogranichena i vklyuchaet monoklonalnie antitela, effektivnost kotorix dostigaet 70%. lechenie gemorragicheskix lixoradok preimushestvenno podderjivayushee, vklyuchaya infuzionnuyu terapiyu dlya korrektsii gipovolemii i simptomaticheskoe lechenie, s letalnostyu do 15% v zavisimosti ot virusa. spasibo za vnimanie @taqdimot_robot

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powerpoint presentation vozbuditeli gemorragicheskoy lixoradki, shoxruz tulaganov 1. diagnostika, profilaktika i lechenie 2. mexanizmi patogeneza i peredachi 3. virusi gemorragicheskix lixoradok: obzor plan: patogenez i mexanizmi zabolevaniya virusnie chastitsi, pronikaya v kletki-misheni (endotelialnie kletki, makrofagi), indutsiruyut apoptoz i nekroz, vizivaya povrejdenie sosudistoy stenki i narushenie gemostaza, chto privodit k razvitiyu krovoizliyaniy razlichnoy stepeni virajennosti. v patogeneze klyuchevuyu rol igrayut narusheniya koagulyatsii, proyavlyayushiesya v vide dvs-sindroma v 30-70% sluchaev, obuslovlennie kak pryamim povrejdeniem endoteliya, tak i aktivatsiey kaskada svertivaniya krovi. replikatsiya virusa v kletkax vizivaet moshniy tsitokinoviy shtorm, xarakterizuyushiysya ...

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