proteinopatii

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powerpoint presentation proteinopatii safaev xushnud plan: 1. belkovie patologii: opredelenie i klassifikatsiya 2. klinicheskie proyavleniya i lechenie proteinopatiy 3. molekulyarnie mexanizmi proteinopatiy primeri proteinopatiy altsgeymerskaya bolezn, yavlyayushayasya rasprostranyonnoy neyrodegenerativnoy proteinopatiey, svyazana s nakopleniem amiloidnix blyashek (bolee 40%) i neyrofibrillyarnix klubkov, narushayushix sinapticheskuyu peredachu. primerom proteinopatii yavlyaetsya amiloidoz, xarakterizuyushiysya otlojeniem nepravilno svyornutix belkov v razlichnix organax, privodyashee k disfunktsii bolee chem v 20 tkanyax i vizivaya seryoznie zabolevaniya. izvestnie proteinopatii amiloidozi, gruppa bolee 30 razlichnix zabolevaniy, xarakterizuyutsya otlojeniem anomalnix belkovix fibrill v razlichnix organax i tkanyax, narushaya ix funktsiyu. pri bolezni gentingtona nepravilno svyornutiy belok xantingtin obrazuet agregati v neyronax golovnogo mozga, chto privodit k neyrodegeneratsii i xarakternim dvigatelnim narusheniyam. chto takoe proteinopatii? mnogie proteinopatii, naprimer, bolezn altsgeymera i bolezn parkinsona, xarakterizuyutsya nakopleniem anomalnix belkov v spetsificheskix oblastyax golovnogo mozga, vizivaya znachitelnie kognitivnie i motornie narusheniya. proteinopatii predstavlyayut soboy gruppu bolee chem 100 zabolevaniy, svyazannix s nepravilnoy svertivaemostyu ili agregatsiey belkov, …

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inopatiy i privodit k energeticheskomu defitsitu, usugublyaya progressirovanie zabolevaniya, snijaya prodoljitelnost jizni. nakoplenie anomalnix belkov v organax i tkanyax, xarakternoe dlya mnogix proteinopatiy, chasto vizivaet fibroz i vospalenie, snijaya funktsionalnost na 50-70%. profilaktika proteinopatiy regulyarnie fizicheskie nagruzki, ne menee 150 minut v nedelyu umerennoy intensivnosti, snijayut risk razvitiya mnogix proteinopatiy, uluchshaya metabolizm i kletochnuyu funktsiyu. sbalansirovannaya dieta, bogataya antioksidantami (bolee 5 portsiy fruktov i ovoshey ejednevno) i ogranichennaya nasishennimi jirami (<10% ot obshey kaloriynosti), sposobstvuet predotvrasheniyu okislitelnogo stressa, faktora riska proteinopatiy. mexanizmi razvitiya proteinopatiy mutatsii v genax, kodiruyushix belki, vizivayut sintez belkov s izmenyonnoy strukturoy (bolee 1000 mutatsiy opisani dlya otdelnix proteinopatiy), snijaya ix funktsionalnost i uvelichivaya sklonnost k agregatsii. narushenie protsessinga belka, vklyuchaya nepravilnoe svorachivanie (do 70% proteinopatiy), mojet privodit k obrazovaniyu amiloidnix fibrill i agregatsii belkov. klassifikatsiya proteinopatiy proteinopatii klassifitsiruyutsya po tipu porajennogo belka, naprimer, amiloidozi (bolee 30 tipov) ili taupatii (svyazannie s tau-belkom), chto vliyaet na vibor …

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aniy proteinopatiy lechenie proteinopatiy transplantatsiya organov, v chastnosti, pecheni, effektivna pri nekotorix proteinopatiyax, dostigaya 70-80% uspexa v zavisimosti ot konkretnogo zabolevaniya i stadii. primenenie preparatov, snijayushix vyazkost krovi, naprimer, plazmaferez, pokazano u patsientov s gipervyazkostnimi proteinopatiyami, uluchshaya mikrotsirkulyatsiyu i snijaya risk trombozov. diagnostika proteinopatiy identifikatsiya spetsificheskix mutantnix belkov provoditsya s pomoshyu metodov mass-spektrometrii, obespechivaya tochnost opredeleniya bolee 95% v opredelyonnix tipax proteinopatiy. geneticheskoe testirovanie, vklyuchayushee sekvenirovanie dnk, neobxodimo dlya podtverjdeniya diagnoza pri podozrenii na bolee chem 30 nasledstvennix proteinopatiy. prichini proteinopatiy posttranslyatsionnie modifikatsii, takie kak glikozilirovanie ili okislenie, mogut izmenyat konformatsiyu belkov, snijaya ix rastvorimost i povishaya sklonnost k agregatsii, chto yavlyaetsya odnim iz mexanizmov razvitiya mnogix proteinopatiy. geneticheskie mutatsii, zatragivayushie do 10% genov, kodiruyushix belki, mogut privodit k sintezu anomalnix belkov, nesposobnix k pravilnomu foldingu, chto zapuskaet patologicheskie protsessi proteinopatiy. spasibo za vnimanie @taqdimot_robot image4.jpg image5.jpg image6.jpg image7.jpg image8.jpg image9.jpg image10.jpg image11.jpg image12.jpg image13.jpg image14.jpg image15.jpg image1.jpeg image2.jpeg

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powerpoint presentation proteinopatii safaev xushnud plan: 1. belkovie patologii: opredelenie i klassifikatsiya 2. klinicheskie proyavleniya i lechenie proteinopatiy 3. molekulyarnie mexanizmi proteinopatiy primeri proteinopatiy altsgeymerskaya bolezn, yavlyayushayasya rasprostranyonnoy neyrodegenerativnoy proteinopatiey, svyazana s nakopleniem amiloidnix blyashek (bolee 40%) i neyrofibrillyarnix klubkov, narushayushix sinapticheskuyu peredachu. primerom proteinopatii yavlyaetsya amiloidoz, xarakterizuyushiysya otlojeniem nepravilno svyornutix belkov v razlichnix organax, privodyashee k disfunktsii bolee chem v 20 tkanyax i vizivaya seryoznie zabolevaniya. izvestnie proteinopatii amiloidozi, gruppa bolee 30 razlichnix zabolevaniy, xarakterizuyutsya otlojeniem anomalnix belkovix fibrill v r...

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