practical training №9

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practical training №9 theme: “clinical pharmacology of drugs which effect on bronchial conductance” distributing materials: 1. adrenomimetics action mechanism. indices epinephrine norepinephrine mesatone ephedrine isadrine heart beats accelerate slows slows accelerate accelerate myocardium +++ + - + ++++ arterial pressure increases increases increases increases increases pressor effect degree 1 2 0,05 - 0,1 0,02 - pressor effect duration 1 2 3-5 7-10 - bronchial dilating +++ + + ++ +++ effect on carbohydrate metabolism ++++ - - + +++ comment: duration and degree of adrenomimetic and pressor effects of substances equal to 1, compared with adrenaline (+++) - high impact; (+) - changing effect; (-) - no effect. 2. action mechanism of drugs which effect on bronchial conductance 3. pde-4 inhibition mechanism 4. theophylline half-life impact factors factors, affecting to theophylline metabolism half life first period ( г | , ). с non-smokers 4-16 (average 8.7) children 3.5 liver cirrhosis …

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drotartras (б) tc: 0,2% solution 2-4 ml (0,004-0,008)- i/v (dropping 1%-5% with glucose solution) 0.2% solution of 1 ml ampoules mesatonum (б) tc: 0,001-0,025 – internal use, 0,003-0,005-u/s; w/m, 0,001-0,003-v/i дк:0,25-0,5% 2-3 drops of solution nose; 1-2% solution of conjunctiva cavity юм: 0,03 - – internal use, 0,01-u/s, w/m; 0,005 i/v hdc: 0,15 - – internal use; 0,05-u/s, w/m; 0,025-i/v powder; 1% solution of 1 ml ampoules naphthyzinum дк: 0,05-0,01% 1-2 drops of solution nose children: 1-2 drops of 0.05 -0,025% solution (1 year later) powder: 0.5-1% solution, 10 ml vials; isadriinum tc; 0.5 - 0.01% solution of 0.1 - 0.2 ml - for inhalation; 0,005 - under the tongue powder; 0.5-1% solution of 25-100 ml vials; tablets - 0,005 salbutamolum tc: 0,002 – – internal use 0,0001 – for inhalation tablets - 0.002 inhalation aerosol (1 inhalation - 0.0001), 0.5% solution in vials fenoterol for inhalation, 1 dose 0,2 …

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dren: until 2 years, not applicable powder libexinum tc: 0,1 – – internal use children: 0,25 (until 2 years) 0,05 (after 2 years) tablets 0,1 claucini hydrochloridum (б) children: 1 mg ( every age, older than 2 yars) tablets 0,05 tusuprex tc: 0,1-0,2 – – internal use children: 0,005 ((until 2 years) 0,01 (after 2 years) tablets 0,05 expectorants infusum herbae thermopsidis tc: 15 ml tincture 1: 300 - – internal use; tincture - 1:300 юм: 0,1 - ( dry herbal mass) - internal use; hdc: 0,3 - internal use tincture 1:300 kalii jodidum tc: 0,3-1.0 (1-3% solution) - – internal use powder tripsinum crystallisatum tc: 0,005-0,01 - inhalation; w/m children: 0,0025 – 1 time/day 0,005; substance 0.01 ampoules and vials substances, used in bronchial asthma euphillinum (б) tc: 0,1-0,15 – internal use 0,3-0,5 – rectal (for enema); 0,24-0,36 – w/m; 0,12 – i/v; юм: 0,5 – – internal use; …

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0 - 2000 mg / day doses of risk increases hemorrhagic rash beclomethasone dose of 400 - 2000 mg / day doses of risk increases dysphonia no clinical importance candisosis less than 5% ., decrease when buffer nozzle is used stopping the growth experiments didn`t show the stoppage of growth image1.png image2.png image3.jpeg

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practical training №9 theme: “clinical pharmacology of drugs which effect on bronchial conductance” distributing materials: 1. adrenomimetics action mechanism. indices epinephrine norepinephrine mesatone ephedrine isadrine heart beats accelerate slows slows accelerate accelerate myocardium +++ + - + ++++ arterial pressure increases increases increases increases increases pressor effect degree 1 2 0,05 - 0,1 0,02 - pressor effect duration 1 2 3-5 7-10 - bronchial dilating +++ + + ++ +++ effect on carbohydrate metabolism ++++ - - + +++ comment: duration and degree of adrenomimetic and pressor effects of substances equal to 1, compared with adrenaline (+++) - high impact; (+) - changing effect; (-) - no effect. 2. action mechanism of drugs which effect on bronchial conductance 3. pde-4 …

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