geo george thomas house surgeon
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surgical site infection geo george thomas house surgeon general surgery surgical site infection-prevention organisms causing ssi mc - staphylococcus aureus any organism like clostridia,gram negative bacteria can cause ssi colonization - bacteria present in a wound with no symptoms/signs of systemic inflammation contamination - transient exposure of wound to bacteria,usually less than 6 hrs. physiology protective mechanisms are compromised by surgical intervention and treatment. mechanical barrier-skin chemical-low gastric ph humoral- antibodies, complement, opsonin cellular- phagocytic cells, macrophages, pmnl, killer lymphocytes risk factors for increased risk of wound infection metabolic disease- diabetes, uremia, jaundice malnutrition( obesity, weight loss) immunosuppression- cancer, ai...
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