laboratornaya diagnostika diareynix virusnix infektsiy

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powerpoint presentation diareynie virusi, klassifikatsiya, patogenez, laboratornaya diagnostika norboev dilshodbek 1. laboratornaya diagnostika diareynix virusnix infektsiy 2. patogenez diareynix virusnix infektsiy 3. virusi, vizivayushie diareyu: klassifikatsiya plan: klinicheskie proyavleniya diareynix virusnix infektsiy adenovirusi, pomimo diarei, vizivayut respiratornie simptomi v 20-40% sluchaev, sochetaya gastroenterit s kon'yunktivitom i/ili ostrim respiratornim zabolevaniem. pri diaree, vizvannoy rotavirusami, u 50-80% detey mladshe 5 let nablyudaetsya lixoradka do 39°c, rvota i obezvojivanie razlichnoy stepeni tyajesti. vvedenie v diareynie virusi diareynie virusnie infektsii xarakterizuyutsya shirokim spektrom klinicheskix proyavleniy, ot lyogkoy diarei do tyajyoloy degidratatsii i letalnogo isxoda. diareynie virusi vizivayut bolee 2 milliardov sluchaev zabolevaniya ejegodno, privodya k znachitelnoy smertnosti, osobenno sredi detey v razvivayushixsya stranax. astrovirusi: patogenez i klinicheskaya kartina patogenez astrovirusnoy infektsii vklyuchaet prikreplenie virusa k retseptoram enterotsitov, replikatsiyu v kletkax tonkoy kishki, chto privodit k povrejdeniyu vorsinok i narusheniyu vsasivaniya pitatelnix veshestv. bolee 20 serotipov astrovirusov, razlichayushixsya po antigennoy strukture, tsirkuliruyut v populyatsii cheloveka, …

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1-3 dnya, pri etom virusnaya nagruzka dostigaet 10 8 –10 12 virionov v gramme fekaliy. patogenez rotavirusnoy infektsii vklyuchaet prikreplenie virusa k retseptoram enterotsitov tonkoy kishki, privodyashee k povrejdeniyu vorsinok i narusheniyu vsasivaniya, chto proyavlyaetsya diareey i obezvojivaniem. laboratornaya diagnostika diareynix virusnix infektsiy: obshie podxodi viyavlenie rnk-virusov, takix kak rotavirusi i norovirusi, chasto osushestvlyaetsya metodom ptsr s chuvstvitelnostyu bolee 95% i spetsifichnostyu svishe 98%, chto pozvolyaet bistruyu diagnostiku. elektronnaya mikroskopiya, xotya i menee chuvstvitelna (okolo 70%), pozvolyaet vizualizirovat virioni, obespechivaya pryamoe podtverjdenie diagnoza pri visokix titrax virusa v obraztse kala. lechenie i profilaktika diareynix virusnix infektsiy pri lechenii rotavirusnoy infektsii regidratatsiya yavlyaetsya klyuchevim momentom, potrebnost v jidkosti mojet dostigat 50-100 ml/kg vesa v sutki, i eto neobxodimo dlya predotvrasheniya obezvojivaniya. effektivnost vaktsinatsii protiv rotavirusnoy infektsii sostavlyaet okolo 85%, snijaya risk tyajelix form zabolevaniya i gospitalizatsii u detey do 3 let. adenovirusi: patogenez i klinicheskaya kartina bolee 50 serotipov adenovirusov sposobni …

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virusov virusi, vizivayushie diareyu, klassifitsiruyutsya po semeystvam, takim kak caliciviridae (vklyuchaya norovirusi i sapovirusi), reoviridae (rotavirusi), astroviridae i adenoviridae, s uchetom geneticheskix i antigennix svoystv, razlichayushixsya po bolee chem 20 serotipam. bolee 50% sluchaev ostrix diareynix zabolevaniy u detey mladshe 5 let svyazani s rotavirusami (semeystvo reoviridae), kotorie podrazdelyayutsya na a, b, c, i drugie gruppi, razlichayushiesya po genotipu i virulentnosti. metodi molekulyarnoy diagnostiki mikrochipi s dnk-zondami obespechivayut odnovremennuyu detektsiyu neskolkix virusov-vozbuditeley diarei, znachitelno uskoryaya diagnostiku i povishaya eyo effektivnost do 95%. posledovatelnost genoma virusa, poluchennaya metodom sekvenirovaniya novogo pokoleniya (ngs), pozvolyaet ne tolko identifitsirovat virus, no i opredelit ego genotip, chto vajno dlya epidemiologicheskogo analiza i prognozirovaniya. drugie diareynie virusi neklassifitsirovannie virusi, takie kak virusi sapporo-like, sostavlyayut znachitelnuyu, no ploxo izuchennuyu chast etiologii diareynix zabolevaniy, trebuya dopolnitelnix issledovaniy dlya polnoy xarakteristiki. u detey do 5 let rotavirusi yavlyayutsya naibolee chastoy prichinoy tyajelogo degidratiruyushego gastroenterita, vizivaya bolee 2 millionov gospitalizatsiy …

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powerpoint presentation diareynie virusi, klassifikatsiya, patogenez, laboratornaya diagnostika norboev dilshodbek 1. laboratornaya diagnostika diareynix virusnix infektsiy 2. patogenez diareynix virusnix infektsiy 3. virusi, vizivayushie diareyu: klassifikatsiya plan: klinicheskie proyavleniya diareynix virusnix infektsiy adenovirusi, pomimo diarei, vizivayut respiratornie simptomi v 20-40% sluchaev, sochetaya gastroenterit s kon'yunktivitom i/ili ostrim respiratornim zabolevaniem. pri diaree, vizvannoy rotavirusami, u 50-80% detey mladshe 5 let nablyudaetsya lixoradka do 39°c, rvota i obezvojivanie razlichnoy stepeni tyajesti. vvedenie v diareynie virusi diareynie virusnie infektsii xarakterizuyutsya shirokim spektrom klinicheskix proyavleniy, ot lyogkoy diarei do tyajyoloy degidratatsii...

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