kvant biofizikasi elementlari

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o'zr fa fiziologii va biofiziki instituti molekulyar biofizika laboratoriyasi mavzu: «kvant biofizikasi elementlari» ma`ruzachi: ruziyev f. a. reja: yangi sintez qilingan glitsirret kislotasi (grk) hosilalarining membranoaktiv xossalarini va ularning mitoxondriya va tsiklosporin a-sezgir pora darajasida boshqaruvchanlik ta'sir qilish mexanizmlarini o'rganish. shuningdek, geliotrin va cci4 bilan toksik zaharlangan eksperimental xayvonlar jigar mitoxondriyalaridagi salbiy o'zgarishlarni grk hosilalari yordamida korrektsiya qilish. tadqiqotning maqsadi grk va uning hosilalarining mitoxondriya membranasi tsiklosporina- sezgir porasi bilan o'zaro ta'sir qilish mexanizmlarini o'rganish; grk hosilalarining mitoxondriya membranasining passiv transporti va sa2+ - hajmiga ta'sirini o'rganish; grk hosilalarining mitoxondriyaning nafas olish va oksidlanishli fosforlanish parametrlariga ta'sirini tadqiq qilish; grk hosilalarining ionoforlik, antioksidantlik va prooksidantlik xossalarini o'rganish; in vivo tajribalarida geliotrin va ssi4 lar bilan zaxarlangan kalamush jigari mitoxondriyalari membranasi o'tkazuvchanligining holatini o'rganish; in vivo tajribalarida toksik gepatit sharoitida grk hosilalarining korrektsiyalovchi ta'sirini o'rganish. tadqiqotning vazifalari. xayvon xujayrasi apparat goldji tsentrioli mitoxondriya lizosoma endoplazmatik tur yadrocha yadro tsitoplazma tsitoplazmaticheskaya membrana …

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k hosilalarning ta'siri. (im tarkibi: 240 mm saxaroza, 1 mm egta, 1 mkm rotenon, 10 mm tris-nsi, rn-7,4; 1. – nazorat; 2. – tsitizin-etil-gts+sa2+; 3. – tsitizin-izopropil-gts+sa2+; 4. - 2-piridil-gts-amid+sa2+; 5. - sa2+. sa2+ - 100 mkm va gpk - 4 mm; grk hosilalari – 25 mkm). 3-rasm. mitoxondriyalarning sa2+ (a) va gpk (b) – indutsirlangan energiyalangan bo'kish tezligiga grk hosilalarning ta'siri. (im tarkibi: 125 mm ks1, 2,5 mm kn2ro4, 1 mm egta, 5 mm glutamat, 1 mm malat, 10 mm tris-nsi, rn-7,4.; 1. – nazorat; 2. – tsitizin-etil-gts+sa2+; 3. – tsitizin-izopropil-gts+sa2+; 4. - 2-piridil-gts-amid+sa2+; 5. - sa2+ va gpk. sa2+ - 1 mkm va gpk - 4 mm; grk hosilalari – 25 mkm). 4-rasm. mitoxondriyalarning sa2+ (a) va gpk (b) – indutsirlangan energiyalangan bo'kish tezligiga grk hosilalarning ta'siri. (sa2+ kontsentratsiyasi - 1 mkm; gpk-4 mm). a) b) * 5-rasm. mitoxondriyalarning sa2+ (a) va gpk (b) – indutsirlangan energiyalanmagan bo'kish …

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22,2±0,8 4,01±0,05 2,72±0,04 2-piridil-gts-amid 99,7±2,4 23,0±0,7 4,33±0,05 2,90±0,03 tsitizin-izopropil-gts 109,9±2,5 24,6±0,6 4,46±0,06 2,93±0,03 tsitizin-etil-gts 112,7±2,7 24,7±0,6 4,56±0,06 2,97±0,04 gpk 71,8±1,7 23,63±0,6 3,04±0,02 1,90±0,01 2-piridil-gts-amid +gpk 77,8±1,6 21,6±0,8 3,60±0,05 2,57±0,03 tsitizin-izopropil-gts+gpk 80,7±1,7 21,1±0,8 3,83±0,05 2,60±0,03 tsitizin-etil-gts +gpk 84,4±2,0 21,1±0,9 4,00±0,04 2,66±0,03 tablitsa 4. kalamush jigari mitoxondriyalari nafas olish va of parametlariga grk hosilalariing ta'siri. eslatma* - v3, v4 ng-atom o/min * mg mx oqsili. sharoit v3 v4 nk adf/o glutamat-malat nazorat 89,02±1,43 22,20±0,61 4,01±0,10 2,72±0,04 tg 78,03±1,05 38,30±0,94 2,03±0,03 1,88±0,01 tg+2-piridil-gts-amid 81,60±1,10 32,50±0,31 2,51±0,05 2,44±0,01 tg+ tsitizin- izopropil-gts 84,25±1,25 30,50±0,28 2,76±0,06 2,49±0,02 tg+tsitizin-etil-gts. 85,30±1,30 27,40±0,73 3,08±0,08 2,53±0,03 e'tiboringiz uchun rahmat!!! diagramma1 12 12 12 12 12 11.76 7.64 9.07 10 10.97 11.44 5.57 6.89 8.17 10.25 11.29 4.45 5.89 7.16 9.78 11.26 3.87 5.25 6.68 9.52 11.22 3.55 5.04 6.47 9.52 12 11.93 12.04 12 12 11.76 7.64 9.55 10.45 11.6 11.44 4.3 7.53 8.75 10.71 11.29 3.02 6.26 7.74 9.86 …

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26 11.22 12 6.55 4.51 3.79 3.42 3.24 11.93 7.64 3.55 2.28 1.8 1.74 12 8.59 6.49 5.47 4.99 4.87 12.04 9.07 6.49 5.11 4.69 4.45 12 10 8.53 7.51 7.15 7.03 12 10.03 8.4 7.45 6.85 6.67 12 10.97 10.25 9.78 9.52 9.52 12 11.6 10.71 9.86 9.2 8.91 diagramma1 1 1 1 1 25 25 25 25 50 50 50 50 75 75 75 75 100 100 100 100 nazorat 2-piridil-gts-amid tsitizin-izopropil-gts tsitizin-etil-gts kontsentratsiya, mkm a/ao 1 0.751 0.64 0.477 1 0.608 0.422 0.247 1 0.52 0.312 0.16 1 0.499 0.29 0.153 list1 25 50 75 100 nazorat 1 1 1 1 1 2-piridil-gts-amid 1 0.751 0.608 0.52 0.499 tsitizin-izopropil-gts 1 0.64 0.422 0.312 0.29 tsitizin-etil-gts 1 0.477 0.247 0.16 0.153 diagramma1 1 1 1 1 25 25 25 25 50 50 50 50 75 75 75 75 100 100 100 100 nazorat 2-piridil-gts-amid tsitizin-izopropil-gts tsitizin-etil-gts kontsentratsiya, mkm …

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orfolin-gts 1 1.53 1.9 2.12 2.23 grk 1 1.77 2.22 2.49 2.59 diagramma1 ca ca ca ca ca ca ca ca ca h h h h h h h h h k k k k k k k k k na na na na na na na na na mg mg mg mg mg mg mg mg mg ba ba ba ba ba ba ba ba ba kontrol 25 mkm 50 mkm 100 mkm kontrol 25 mkm 50 mkm 100 mkm a/ao 1 13.7 18.4 25.2 1 10.3 16.5 22 1 7.2 11.3 17.4 1 6.5 10.8 15 1 5.5 9.8 11.7 1 5 9.1 10.8 1 3.2 5.6 7 1 3 5.5 6.5 1 2.4 4.1 5 1 2.4 4.2 5 1 2.2 3.6 4.5 1 2.2 3.6 4.5 diagramma3 ca ca ca ca h h h h k k k k na na na na mg mg mg …

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o'zr fa fiziologii va biofiziki instituti molekulyar biofizika laboratoriyasi mavzu: «kvant biofizikasi elementlari» ma`ruzachi: ruziyev f. a. reja: yangi sintez qilingan glitsirret kislotasi (grk) hosilalarining membranoaktiv xossalarini va ularning mitoxondriya va tsiklosporin a-sezgir pora darajasida boshqaruvchanlik ta'sir qilish mexanizmlarini o'rganish. shuningdek, geliotrin va cci4 bilan toksik zaharlangan eksperimental xayvonlar jigar mitoxondriyalaridagi salbiy o'zgarishlarni grk hosilalari yordamida korrektsiya qilish. tadqiqotning maqsadi grk va uning hosilalarining mitoxondriya membranasi tsiklosporina- sezgir porasi bilan o'zaro ta'sir qilish mexanizmlarini o'rganish; grk hosilalarining mitoxondriya membranasining passiv transporti va sa2+ - hajmiga ta'sirini o'rganish; grk ho...

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