immunological incompatibility between mother and fetus

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immunologicheskaya nesovmestimost mejdu materyu i plodom ona va xomila orasidagi immunologik konflikt - immunological incompatibility between mother and fetus professor g.s. babadjanova xomila gemolitik kasalligi – hemolytic disease of the fetus eritrotsitlar gemolizi natijasida xosil bulgan kamkonlik, sariklik va konda blast eritrotsitlarni kupayishi bilan ifodalanadigan axvolni xomila gemolitik kasalligi deb ataladi this state of the fetus, caused by hemolysis of red blood cells, characterized by anemia, jaundice and an increase in the number of blast erythrocytes in the bloodstream xgk realizatsiyasi uchun 2 shart bulishi lozim - to realize hdn needed 2 conditions 1.oldin alloimmunizatsiya bulganligi: a) retsipientda mavjud bulmagan antigenli donorni koni yoki eritrotsitar massasi kuyilgan bulsa b) ikkita narkoman bitta shprits bilan foydalangan bulsa 1. alloimmunization before: a) transfusion of whole blood or packed red blood cells from a donor antigen, which is absent in the recipient b) when using a two syringe addicts v) xomiladorlik davrida,ayniksa tugrukni …

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5%-da aniklanadi. ushbu antigen eritrotsitlarda mavjud bulsa kon rezus-musbatli deb xisoblanadi. eritrotsilarida antigen bulmagan odamlar koninini rezus-manfiy deb xisoblanadi. antigen rh0 (d), a core antigen rh. it is found in the red blood cells of 85% of people living in europe. due to the presence of this antigen on erythrocytes distinguish rh-positive blood type. the blood of people whose red blood cells do not contain the antigen referred to as rh- are negative type chakaloklar gemolitik kasalligini etiologiya va patogenezi - the etiology and pathogenesis of hdn rezus-manfiy ayolni rezus-musbat erkandan xomilador bulishini imkoniyati 85% bulishi mumkin, shunda rh(+)li chakalok tugilishi imkoniyati 60% tashkil etadi. xomila koni ona koniga tushishi alloimmunizatsiyaga sharoit tashkil etadi. the probability of an rh-negative woman from becoming pregnant rh-positive men - 85%, while the probability of a birth rh (+) of the fetus is about 60%. after contact with the blood of the fetus in …

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oombs' reaction igg turiga kiradigan antitanachalar yuldosh orkali xomila kon tizimiga utib, xomila eritrotsitlarini gemoliziga olib keladilar. bu xomilada kamkonlik va i giperbilirubinemiyaga olib keladi. antibodies belong to the class igg, cross the placenta in fetal blood stream and cause hemolysis of fetal erythrocytes, which in turn leads to anemia, hyperbilirubinemia xomila gemolitik kasalligi - clinical sings xomila axvoli va zararlanishini ogirligi antitanachalarga boglik: 1.ona konida antitanachalar kontsentratsiyasiga 2.yuldosh orkali utish darajasiga 3.antitanachalar utish davomiyligiga the status of the embryo and losses related to antibodies: concentration of antibodies in mother blood. through go antibodies from placenta. the duration go the ntibodies anemiya tokimalar gipoksiyasiga va yurak etishmovchilikga olib keladi. lekin giperbilirubinemiya tugrukdan keyin muammo bulib koladi. chakaloklar gemolitik kasalligi 3 turda buladi: shishli, sariklik, anemik. anemia leads to tissue hypoxia and heart failure hyperbilirubinemia is becoming an urgent problem after childbirth there are three clinical forms of hemolytic disease of …

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aklarda, ularni kattalashishi, endokrin va limfoid tizim dekompensatsiyasi, parenximatoz a'zolarda distrofik va nekrotik uzgarishlar. yurak kattalashgan. 2. istisxo (shishli turi) chakalok chala tugilgan buladi, kupincha ulgan yoki birinchi soatlarida nobut buladi korni shishgan, teri osti katlami yakkol kurinarli shishgan (budda sindromi) astsit, jigar va talokni xaddan tashkari kattalashganligi uta ogir kamkonlik va eritrotsitlarni etishmagan turlarini kupayishi yurak bushliklari kengaygan,gidrotoraks * platsenta kurinishi yuldoshni yakkol kurinarli shishganligi (5sm) ulchamlarini kattalashishi xajmi xomila vaznini 50% tashkil etadi xomila buyraklari ajratib turgan zardob pigmentlari yuldosh va uni pardalarini sarik rangga buyyalganligi. sariklik turi (ogir shakli) teri okargan va sargimtir jigar va talok kattalashgan gemorragik sindrom, mns zararlanganligi retikulotsitozli va normoblastozli kamkonlik bilirubin konda 130-170 mmol/l, xar soatda 3,5 - 17 mmol/l ga kupayishi vaktida davolansa xayotini saklab kolsa buladi anemik formasi (engil shakli) terini rangi okish, sargishrok jigar va talok kattalashgan gemoglobin va eritrotsitlar pasayishi, retikulotsitlar kupayishi bu shakli tugilgan zaxoti yoki ikki …

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tsiyaga, ayniksa miyada, olib keladi. bosh miya funktsiyasi buzilishi, 20-40 % neyronlar nobud bulishi ogir asoratlarga (postsariklik entsefalopatiyaga), 70-90% neyronlar nobud bulishi esa – ulimga olib boradi. 5.tugrukdan keyin sariklik turi (kamkonliksiz sariklik) kliniko-anatomik kurinishi bilirubinli entsefalopatiyaga xos (yadroli sariklik). jigar va talokda kurinarli gemosideroz xomiladorlik vaktida xgk aniklash 1.anamnezni yaxshi yigish a) oldin immunizatsiya bulganligi (anamnezda abort bulganligi axamiyatli) b) akusherlik anamnezi: tirik chakalok gemolitik kasalligi bilan tugilgan bulsa; gemolitik kasallikdan ulgan bulsa; tugrukdan keyin gemolitik kasallikdan ulgan bulsa; gemolitik kasallikdan antenatal ulim onada zardobida antitatnachalar kupligi (kumbs sinamasi yordamida aniklanadi) xgk xomiladorlik davrida tashxislash 1.ona konida zardobli antitanachalar titrlarini aniklash (kumbs sinamasi) 2. ultratovush markerlari: - yuldosh kalinligi 50 mm ziyod - kupsuvlik, gidroperikard - yurak ulchamlarini kattalashishi - astsit, gepatosplenomegaliya xgkni diagnostikasi (davomi) - ter-osti katlamini shishi 3. xomila konini aniklash yoki amniotik suvlarni tekshirish (davomi) 4. xomilador ayol konida antitanachalarni va ularni titrini aniklash xomilador ayollarda …

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О "immunological incompatibility between mother and fetus"

immunologicheskaya nesovmestimost mejdu materyu i plodom ona va xomila orasidagi immunologik konflikt - immunological incompatibility between mother and fetus professor g.s. babadjanova xomila gemolitik kasalligi – hemolytic disease of the fetus eritrotsitlar gemolizi natijasida xosil bulgan kamkonlik, sariklik va konda blast eritrotsitlarni kupayishi bilan ifodalanadigan axvolni xomila gemolitik kasalligi deb ataladi this state of the fetus, caused by hemolysis of red blood cells, characterized by anemia, jaundice and an increase in the number of blast erythrocytes in the bloodstream xgk realizatsiyasi uchun 2 shart bulishi lozim - to realize hdn needed 2 conditions 1.oldin alloimmunizatsiya bulganligi: a) retsipientda mavjud bulmagan antigenli donorni koni yoki eritrotsitar massasi kuyil...

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