molecular mechanisms in signal transduction at the membrane

molecular mechanisms in signal transduction at the membrane jay t groves1,2,3,4 and john kuriyan1,2,3,4 1departments of chemistry, university of california, berkeley, california, usa 2molecular and cell biology, university of california, berkeley, california, usa 3howard hughes medical institute, university of california, berkeley, california, usa 4physical biosciences division, lawrence berkeley national lab, berkeley, california, usa abstract signal transduction originates at the membrane, where the clustering of signaling proteins is a key step in transmitting a message. membranes are difficult to study, and their influence on signaling is still only understood at the most rudimentary level. recent advances in the biophysics of membranes, surveyed in this review, have highlighted a vari...

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